{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T19:44:04Z","timestamp":1779392644563,"version":"3.53.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":664,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>Bleeding after dental extractions is very frequent in patients with von Willebrand disease (vWD) and in the past often necessitated transfusions with factor VIII\/von Willebrand factor concentrates (vWFc). To evaluate the benefits of a standard local therapy on bleeding complications during oral surgery, 63 consecutive patients with vWD were analysed retrospectively. All types of vWD were included: type 1 (<jats:italic>n<\/jats:italic>=31), type 2 (<jats:italic>n<\/jats:italic>=22) and type 3 (<jats:italic>n<\/jats:italic>=10). All the patients had dental extractions or periodontal surgery at the same hospital by the same oral surgeons. All cases had been given tranexamic acid (TA) before and for 7 days after surgery. As additional local therapy fibrin glue (FG) was used during surgery in several patients. Additional systemic therapies were: desmopressin (DDAVP, 0.3\u2003\u03bcg\u2003kg<jats:sup>\u20131<\/jats:sup>) and fVIII\/vWF concentrates (vWFc, 40\u2003U\u2003kg<jats:sup>\u20131<\/jats:sup>) given as a single dose before surgery. The 29 subjects (46%) treated locally did not bleed. Among the remaining cases, 24 (38%) were given DDAVP as additional systemic therapy and 6 (9.5%) received vWFc. There was bleeding after surgery in only two cases who had been given local FG (type 2 B) or systemic vWFc (type 3), but bleeding was stopped with an additional local application of FG. Our data suggest that a standard local therapy with TA and FG with DDAVP can prevent bleeding complications during oral surgery in the majority of patients (84%) with vWD and reduce the need for concentrates, with all their possible complications and high costs.<\/jats:p>","DOI":"10.1046\/j.1365-2516.2000.00370.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T23:01:14Z","timestamp":1047423674000},"page":"71-77","source":"Crossref","is-referenced-by-count":58,"title":["Optimising local therapy during oral surgery in patients with von Willebrand disease: effective results from a retrospective analysis of 63 cases"],"prefix":"10.1111","volume":"6","author":[{"family":"Federici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Stabile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Carpenedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Zingaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Mannucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.440654.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.440661.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(90)90335-P"},{"key":"e_1_2_6_5_2","first-page":"289","article-title":"Actual management of von Willebrand disease (vWD): report on 1257 cases of the Italian Registry of vWD. (Abstract)","volume":"4","author":"Federici AB","year":"1998","journal-title":"Haemophilia"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(85)90106-9"},{"key":"e_1_2_6_7_2","first-page":"263","article-title":"Les extractions dentaires chez les h\u00e9mophiles et les porteurs de la maladie de Willebrand. Propositions th\u00e9rapeutiques \u00e0 propos de 26 observations","volume":"95","author":"Piot B","year":"1994","journal-title":"Rev Stom Chir Maxillof"},{"key":"e_1_2_6_8_2","first-page":"621","article-title":"Prevention of hemorrhage and dental treatment of patients with congenital or acquired coagulopathies","volume":"46","author":"Vangelisti R","year":"1997","journal-title":"Minerva Stomatol"},{"key":"e_1_2_6_9_2","first-page":"115","article-title":"Treatment of the patient with a coagulation defect in oral and maxillofacial surgery: III. The management of patients in a hypocoagulative state because of a hemophilic\u2010type primary pathology","volume":"46","author":"Chiarini L","year":"1997","journal-title":"Minerva Stomatol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-4356(98)90178-4"},{"key":"e_1_2_6_11_2","first-page":"362","article-title":"Local hemostatic of oral bleeding in patients with coagulopathie","volume":"101","author":"Suzuki H","year":"1983","journal-title":"Lancet"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(86)90039-X"},{"key":"e_1_2_6_13_2","first-page":"332","article-title":"DDAVP and EACA used for minor oral surgery in von Willebrand disease","volume":"5","author":"Williamson R","year":"1988","journal-title":"Aust Dent J"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903303201305"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90135-Q"},{"key":"e_1_2_6_16_2","first-page":"961","article-title":"Local antifibrinolytic treatment with tranexamic acid in hemophilic children undergoing dental extractions","volume":"41","author":"Waly NG","year":"1995","journal-title":"Egypt Dent J"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1055\/s-0038-1642726","article-title":"Fibrin sealant in surgery of patients with a hemorrhagic diathesis","volume":"74","author":"Martinowitz U","year":"1995","journal-title":"Thromb Haemostas"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80210-1"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.t01-1-00283.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1055\/s-0038-1642471","article-title":"A revised classification of von Willebrand disease","volume":"71","author":"Sadler JE","year":"1994","journal-title":"Thromb Haemost"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1182\/blood.V85.2.598.598","article-title":"Guidelines for management of hemophilia A and B","volume":"85","author":"Djulbegovic B","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-4220(06)80099-X"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb08921.x"},{"key":"e_1_2_6_24_2","first-page":"224","article-title":"Post\u2010DDAVP thrombocytopenia in type IIB von Willebrand disease is not associated with platelet consumption: failure to demonstrate glycocalicin increase or platelet activation","volume":"81","author":"Casonato A","year":"1998","journal-title":"Thromb Haemostas"},{"key":"e_1_2_6_25_2","first-page":"121","article-title":"Myocardial infarction in a patient with hemophilia treated with DDAVP (letter)","volume":"318","author":"Bond L","year":"1998","journal-title":"N Engl J Med"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.0040s3007.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2516.2000.00370.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2516.2000.00370.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2516.2000.00370.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T10:38:22Z","timestamp":1698575902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2516.2000.00370.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["10.1046\/j.1365-2516.2000.00370.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2516.2000.00370.x","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}