{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:55:04Z","timestamp":1789728904577,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":664,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>A consecutive series of 16 patients with classical Haemophilia underwent 21 total knee replacements between 1989 and 1997 for haemophilic arthropathy. The patients received Factor VIII replacement therapy via continuous infusion, and fibrin glue was used to facilitate haemostasis. Three different types of prostheses were used. A follow\u2010up evaluation was undertaken between 2 and 10 years after the operation (mean 5.6\u2003years) and two patients with infection were excluded. Knee scores averaged 77.5 (pre\u2010operative 24.1) and functional scores averaged 84.4 (preoperative 23.2). There were no cases with aseptic loosening of the prosthesis. Complications included one early deep infection controlled by conversion of the TKR into an arthrodesis, one case of late septic loosening that had to be re\u2010operated upon, one case of patellar dislocation, two cases of stiff knee (fibro\u2010arthrosis) that required manipulation under anaesthesia, one postoperative hepatitis, one superficial infection treated by incision and drainage and four febrile patients with no clear source of infection, who responded to antibiotics alone. In conclusion, TKR offers haemophilic patients a long\u2010lasting improvement of their quality of life and we therefore advocate its use with the appropriate indications.<\/jats:p>","DOI":"10.1046\/j.1365-2516.2000.00375.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T23:01:14Z","timestamp":1047423674000},"page":"104-109","source":"Crossref","is-referenced-by-count":87,"title":["Orthopaedic outcome of total knee replacement in Haemophilia A"],"prefix":"10.1111","volume":"6","author":[{"family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Heim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Martinowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Chechick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"98","article-title":"Total knee arthroplasty for the treatment of chronic hemophilic arthropathy","volume":"248","author":"Figgie MP","year":"1989","journal-title":"Clin Orthop Rel Res"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00003086-199007000-00021","article-title":"Total knee arthroplasty in classic hemophilia","volume":"256","author":"Kjaersgaard\u2010Andersen P","year":"1990","journal-title":"Clin Orthop Rel Res"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.70B3.3131346"},{"key":"e_1_2_5_5_2","first-page":"471","article-title":"Continuous infusion of coagulation products","volume":"1","author":"Martinowitz U","year":"1994","journal-title":"Int J Pediatr Hamatol Oncol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb06951.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657608"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2106\/00004623-197658060-00003","article-title":"A comparison of four models of total knee replacement prostheses","volume":"58","author":"Insall J","year":"1976","journal-title":"J Bone Joint Surg (Am)"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650292"},{"key":"e_1_2_5_10_2","first-page":"192","article-title":"Total knee replacement in hemophilia","volume":"125","author":"Marmor L","year":"1977","journal-title":"Clin Orthop Rel Res"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200816"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197961010-00013"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198163050-00002"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198567090-00009"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830230405"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3928\/0147-7447-19860501-09","article-title":"Total knee arthroplasty in chronic hemophilic arthropathy","volume":"9","author":"Magone JB","year":"1986","journal-title":"Orthopedics"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453679308994558"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(05)80144-5"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.00183.x"},{"key":"e_1_2_5_20_2","unstructured":"LarcomP&LotkePA.Treatment of inflammatory and degenerative conditions of the knee. 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