{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:45:42Z","timestamp":1761540342263},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2495,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2001,9,7]]},"abstract":"<jats:p>The association between gastrointestinal angiodysplasia and von Willebrand disease was reported 30\u2003years ago. The clinical course of patients with von Willebrand disease and angiodysplasia is characterized by numerous admissions to hospital for gastrointestinal bleeding necessitating transfusion with packed red cells, factor VIII and plasma. The management of these patients is problematic. Numerous treatments for the gastrointestinal bleeding have been proposed: surgery, electrocoagulation, laser photocoagulation, sclerotherapy, arteriography with embolization, immunoglobulins, oestrogens, and octreotide, but no treatment modality has been successful in all cases. We report a 66\u2010year\u2010old\u2010female with small bowel angiodysplasia and von Willebrand type III disease in whom prompt administration of factor VIII\/vWF concentrates was effective. Education of patients to recognize minimal gastrointestinal bleeding manifestations, periodical clinical visits and early infusion of factor VIII\/vWF seems to be fundamental for the success of this therapy. A longer follow\u2010up and the study of other patients are needed to confirm our observation.<\/jats:p>","DOI":"10.1046\/j.1365-2516.2001.00543.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T23:06:27Z","timestamp":1047423987000},"page":"500-503","source":"Crossref","is-referenced-by-count":9,"title":["Early transfusion of factor VIII\/von Willebrand factor concentrates seems to be effective in the treatment of gatrointestinal bleeding in patients with von Willebrand type III disease"],"prefix":"10.1111","volume":"7","author":[{"given":"E.","family":"Zanon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Vianello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Casonato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Girolami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196711000-00002"},{"key":"e_1_2_4_3_2","first-page":"546","article-title":"International survey of patients with von Willebrand disease and angiodysplasia","volume":"79","author":"Fressineaud E","year":"1993","journal-title":"Thromb Haemostas"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830410410"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199902)60:2<151::AID-AJH13>3.0.CO;2-J"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614874"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01897.x"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200103000-00009"},{"key":"e_1_2_4_9_2","first-page":"286","article-title":"Acquired type A von Willebrand\u2019s disease: response to immunoglobulin infusions","volume":"27","author":"Sampson B","year":"1992","journal-title":"Haemostasis"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199204000-00003"},{"key":"e_1_2_4_11_2","first-page":"309","article-title":"The evaluation of factor VIII antigen measuring of a single slide test","volume":"29","author":"Casonato A","year":"1985","journal-title":"Am J Clin Path"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1961.tb00332.x"},{"key":"e_1_2_4_13_2","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1055\/s-0037-1614160","article-title":"Capillary microscopic and rheologic dimensions for the diagnosis of von Willebrand disease in comparison to other haemorrhagic diathesis","volume":"84","author":"Koscienly JK","year":"2000","journal-title":"Thromb Haemost"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.0040s3001.x"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.0040s3033.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2516.2001.00543.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2516.2001.00543.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2516.2001.00543.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T11:53:40Z","timestamp":1697370820000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2516.2001.00543.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9,7]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,9,7]]}},"alternative-id":["10.1046\/j.1365-2516.2001.00543.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2516.2001.00543.x","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9,7]]}}}