{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:04:24Z","timestamp":1785683064887,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":693,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To analyse the relationship between expression of cytotoxic proteins, histopathology and the CD30 status in primary cutaneous T\u2010cell disorders, we investigated the expression of TIA\u20101, granzyme B and perforin in CD30 negative and CD30 positive cutaneous T\u2010cell lymphomas (CTCL) and lymphomatoid papulosis (LP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We studied 26 cases of CTCL and 12 cases of LP for the expression of TIA\u20101, granzyme B and perforin which are granule\u2010associated proteins of cytotoxic lymphocytes involved in the mechanism of apoptosis. We showed that most cases (10\/13) of CD30 negative pleomorphic lymphomas expressed cytotoxic proteins only in scattered, apparently reactive lymphocytes, the exception being one CD8+ CTCL and two \u03b3\u03b4 subcutaneous \u2018panniculitis\u2010like\u2019 T\u2010cell lymphomas. We also showed that at least one cytotoxic protein was expressed in a proportion of neoplastic cells in 77% (10\/13) of CD30+\u2003T\u2010cell lymphomas (3\/4 pleomorphic and 7\/9 anaplastic) and in a proportion of atypical cells in 75% (9\/12) of LP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings show a strong correlation between the CD30 phenotype and the expression of cytotoxic proteins in primary CTCL. In addition, these results provide further evidence for an overlap between lymphomatoid papulosis and cutaneous CD30+ pleomorphic and anaplastic lymphomas. These entities, which belong to the spectrum of CD30 positive cutaneous T\u2010cell lymphoproliferations, appear to be derived from cytotoxic cells.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2559.2000.00799.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T00:07:59Z","timestamp":1047427679000},"page":"136-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Primary CD30\u2010positive cutaneous T\u2010cell lymphomas and lymphomatoid papulosis frequently express cytotoxic proteins"],"prefix":"10.1111","volume":"36","author":[{"family":"Boulland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Wechsler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Bagot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Pulford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Kanavaros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Gaulard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.7.2385.bloodjournal8872385"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930315)71:6<2097::AID-CNCR2820710626>3.0.CO;2-7"},{"key":"e_1_2_6_4_2","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas: a proposal from the cutaneous lymphoma study group of the European Organization for Research and Treatment of Cancer","volume":"90","author":"Willemze R","year":"1997","journal-title":"Blood"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1001\/archderm.1968.01610070029004","article-title":"Lymphomatoid papulosis: a continuing self healing eruption, clinically benign\u2003\u2212\u2003histologically malignant","volume":"97","author":"Macaulay WL","year":"1968","journal-title":"Arch. 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