{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:19:47Z","timestamp":1784603987152,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":511,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p> <jats:italic>Aims<\/jats:italic> <\/jats:p><jats:p>: The causal relationship of <jats:italic>H. pylori<\/jats:italic> gastric colonization with gastric cancer development has not as yet been fully elucidated. The prevalence of <jats:italic>H. pylori<\/jats:italic> infection increases with age in the asymptomatic population in Japan, and reaches a high plateau in those older than 40\u2003years. The objective of this study was to assess the link between <jats:italic>H. pylori<\/jats:italic> and gastric carcinomas in patients younger than 40\u2003years.<\/jats:p><jats:p> <jats:italic>Methods and results<\/jats:italic> <\/jats:p><jats:p>: Detection of <jats:italic>H. pylori<\/jats:italic> and assessment of background mucosa based on the Sydney system was performed histopathologically for 40 Japanese gastric cancer cases younger than 40\u2003years and compared with 40 age\u2010 and sex\u2010matched controls. <jats:italic>H. pylori<\/jats:italic> infection in gastric mucosa was detected significantly more frequently (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) in patients with cancer (29\/40; 72.5%) than in controls (11\/40; 27.5%). Additionally, by histopathological comparison between intestinal (18 cases) and diffuse (70 cases) types of young gastric cancer patients, mucosal atrophy and intestinal metaplasia were found to coexist with acute and chronic inflammation in the background mucosa of both intestinal and diffuse types, being significantly more prevalent than in young controls.<\/jats:p><jats:p> <jats:italic>Conclusions<\/jats:italic> <\/jats:p><jats:p>: As well as the high prevalence of <jats:italic>H. pylori<\/jats:italic> in young subjects with gastric cancer, it is clear that persistent infection induces mucosal damage, resulting in atrophy and intestinal metaplasia. Thus, acute\/chronic gastritis could play an essential role in the early development of neoplasia in the stomach.<\/jats:p>","DOI":"10.1046\/j.1365-2559.2000.00948.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T00:09:26Z","timestamp":1047427766000},"page":"124-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Association of <i>Helicobacter pylori<\/i>\u2010dependent gastritis with gastric carcinomas in young Japanese patients: histopathological comparison of diffuse and intestinal type cancer cases"],"prefix":"10.1111","volume":"37","author":[{"given":"Y","family":"Koshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sasabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Katoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Okayasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0016-5085(89)80057-5","article-title":"Campylobacter pylori and peptic ulcer disease","volume":"96","author":"Graham DY","year":"1989","journal-title":"Gastroenterology"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036078"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000171265"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199244060-00002"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6788.1302"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910460410"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90938-D"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251604"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940601)73:11<2691::AID-CNCR2820731107>3.0.CO;2-2"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950501)75:9<2203::AID-CNCR2820750903>3.0.CO;2-6"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70143-X"},{"key":"e_1_2_6_14_2","first-page":"562","article-title":"Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk","volume":"55","author":"Blaser MJ","year":"1995","journal-title":"Cancer Res."},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90156-S"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.6.800"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008924"},{"key":"e_1_2_6_18_2","first-page":"449","article-title":"Antibodies to Helicobacter pylori and pepsinogen levels in children from Costa Rica: comparison of two areas with different risks for stomach cancer","volume":"1","author":"Sierra R","year":"1992","journal-title":"Cancer Epid. 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