{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:46:06Z","timestamp":1760852766989},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"vor","delay-in-days":295,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p>We report here a case of apocrine adenosis of the breast in a 66\u2010year\u2010old woman. To clarify the nature of this lesion, we examined it by clonal analysis.<\/jats:p><jats:p>The lesion, 43\u2003mm at its greatest dimension, was ill\u2010circumscribed, lacking a fibrous capsule, and was composed of compact glands that showed typical histological features of apocrine adenosis. Clonality analysis, using the polymerase chain reaction (PCR)\u2010based method for females heterozygous for a <jats:italic>Bst<\/jats:italic>XI polymorphism of the X\u2010linked phosphoglycerokinase (PGK) gene, revealed the monoclonal nature of the lesion.<\/jats:p><jats:p>This result strongly suggests that some populations of apocrine adenosis are already neoplastic, and this could contribute to the premalignant potential of this lesion.<\/jats:p>","DOI":"10.1046\/j.1365-2559.2001.01095.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T00:10:42Z","timestamp":1047427842000},"page":"221-224","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Apocrine adenosis of the breast: clonal evidence of neoplasia"],"prefix":"10.1111","volume":"38","author":[{"given":"Y","family":"Endoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Motoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"289","article-title":"Apocrine adenosis \u2013 a mimic of mammary carcinoma","volume":"3","author":"Simpson JF","year":"1990","journal-title":"Surg. 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