{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T07:24:14Z","timestamp":1766820254524},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2440,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:p> <jats:bold>Histological and immunohistochemical characterization of extranodal diffuse large\u2010cell lymphomas with prominent spindle cell features<\/jats:bold> <\/jats:p><jats:p> <jats:italic>Aims<\/jats:italic>:\u2002To describe five cases of diffuse large\u2010cell lymphoma with prominent spindle cell components involving skin, nasal\u2010ocular mucosa, and soft tissue. Because of the spindle cell morphology, such cases must be differentiated from true sarcomas arising in or metastasizing to soft tissue, skin, bone, lymph node, or other organs and sites.<\/jats:p><jats:p> <jats:italic>Methods and results<\/jats:italic>:\u2002Formalin\u2010fixed paraffin\u2010embedded archival tissue from five consultation cases of diffuse large\u2010cell lymphoma with prominent spindle cell features involving the skin, nasal\u2010ocular mucosa, and soft tissue in three male and two female patients was studied by histology and immunohistochemistry. Clinicopathological findings were also reviewed for all the patients. By morphology, initial evaluation of the cases suggested spindle cell sarcoma in two cases, inflammatory pseudotumour in one case, large\u2010cell lymphoma in another case, and one case was considered suspicious for malignant lymphoma. Immunohistochemistry demonstrated a B\u2010cell lineage in four of the spindle cell lesions, with a diagnosis of primary cutaneous CD30+ anaplastic large cell lymphoma made for the fifth case. Four of five cases also showed actin reactivity.<\/jats:p><jats:p> <jats:italic>Conclusions<\/jats:italic>:\u2002Although extremely rare, lymphomas with prominent spindle cell morphology can be encountered in daily surgical pathology practice, and should be included in the differential diagnosis of spindle cell lesions in skin and soft tissue. The observed actin reactivity in four of the five spindle cell lymphomas may lead to a misdiagnosis of leiomyosarcoma if lymphoid markers are not included in the immunohistochemical panel.<\/jats:p>","DOI":"10.1046\/j.1365-2559.2001.01271.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T00:12:22Z","timestamp":1047427942000},"page":"476-481","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Histological and immunohistochemical characterization of extranodal diffuse large\u2010cell lymphomas with prominent spindle cell features"],"prefix":"10.1111","volume":"39","author":[{"given":"J","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N C J","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Nozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Arber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K L","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L M","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"WarnkeRA WeissLM ChanJKC ClearyML DorfmanRF.Tumor of the lymph nodes and spleen. Atlas of tumor pathology.Fascicle 14. Third Series. Washington DC: Armed Forces Institute of Pathology 1995; 176\u2013177."},{"key":"e_1_2_6_3_2","unstructured":"DahlinDC&UnniKK.Bone tumors general aspects and data on 8542 cases 4th edn. Springfield: Charles C Thomas 1986; 208\u2013226."},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841015)54:8<1598::AID-CNCR2820540822>3.0.CO;2-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198901000-00001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199010000-00013"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(99)80132-0"},{"key":"e_1_2_6_8_2","first-page":"1053","article-title":"Actin\u2010positive spindle cell\u2003lymphoma","volume":"117","author":"Fung CHK","year":"1993","journal-title":"Arch. Pathol. Lab. 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