{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T07:47:21Z","timestamp":1794642441862,"version":"4.9.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,1,21]],"date-time":"2002-01-21T00:00:00Z","timestamp":1011571200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p> <jats:bold>Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysis<\/jats:bold> <\/jats:p><jats:p> <jats:italic>Aims<\/jats:italic>:\u2002Malignant thymic tumour histologically resembling a soft tissue sarcoma is extremely rare and defined as sarcomatoid carcinoma in the recent World Health Organization (WHO) classification. We report two such cases in which the tumour cells showed a prominent rhabdomyoblastic differentiation and analyse whether these tumours retain an epithelial nature at least in part.<\/jats:p><jats:p> <jats:italic>Methods and results<\/jats:italic>:\u2002One tumour occurred in a 51\u2010year\u2010old man (Case 1) and the other in a 40\u2010year\u2010old woman (Case 2). Microscopically, both tumours consisted essentially of two types of tumour cells: spindle and large round cells, with no apparent epithelial components. Osteosarcomatous small foci were also found in Case 2. Immunohistochemically, desmin and muscle\u2010specific actin were positive in the majority of both types of tumour cells, whereas myogenin was predominant in the spindle cells and myoglobin in the large round cells. Some of both types of cells expressed cytokeratin with co\u2010expression of myoglobin in the large round cells, but with no myogenin in the spindle cells. Some cytokeratin\u2010positive spindle cells were also negative for desmin. Ultrastructural examination of a recurrent tumour in Case 2 revealed some epithelial features among the spindle cells. Cytogenetic study of the same tumour showed a complex abnormality including der(16)t(1;16)(q12;q12.1), an identical pattern previously reported in a case of thymic squamous cell carcinoma.<\/jats:p><jats:p> <jats:italic>Conclusions<\/jats:italic>:\u2002The findings support the definition in the WHO classification of sarcomatoid carcinoma that includes purely sarcomatous tumour as in the present cases. Occurrence of this type of tumour may indicate a relationship between thymic epithelial cells and myoid cells and\/or a potential for divergent differentiation in thymic epithelial tumours.<\/jats:p>","DOI":"10.1046\/j.1365-2559.2002.01310.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T00:12:43Z","timestamp":1047427963000},"page":"46-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"T","family":"Eimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kitaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Niwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Murase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Tateyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Soji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H J","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","unstructured":"RosaiJ.Histological typing of tumours of the thymus. World Health Organization International Histological Classification of Tumours 2nd edn. Berlin: Springer 1999.","DOI":"10.1007\/978-3-642-60157-6"},{"key":"e_1_2_7_3_2","unstructured":"ShimosatoY&MukaiK.Tumors of the mediastinum. Atlas of tumor pathology 3rd series fascicle 21. Washington DC: Armed Forces Institute of Pathology 1997."},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198207000-00007"},{"key":"e_1_2_7_5_2","first-page":"14","article-title":"Soft tissue neoplasms of the mediastinum","volume":"8","author":"Swanson PE","year":"1991","journal-title":"Semin. Diag. Pathol."},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0022-5223(19)43217-0","article-title":"Tumors of the thymus","volume":"53","author":"Friedman NB","year":"1967","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(72)90050-2"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198210000-00003"},{"key":"e_1_2_7_9_2","first-page":"1375","article-title":"A thymic tumor with massive proliferation of myoid cells","volume":"34","author":"Murakami S","year":"1984","journal-title":"Acta Pathol. Jpn."},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910215)67:4<1025::AID-CNCR2820670427>3.0.CO;2-F"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1992.tb00385.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1997.tb04489.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199306000-00012"},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/ajcp\/94.1.36","article-title":"Nonneoplastic and nonhyperplastic thymus in myasthenia gravis. An immunohistochemical study with double immunoenzymatic labeling of basement membrane and cellular components","volume":"94","author":"Eimoto T","year":"1990","journal-title":"Am. J. Clin. Pathol."},{"key":"e_1_2_7_15_2","unstructured":"MitelmanF. ISCN (1995): An International System for Human Cytogenetic Nomenclature. Basel: Krager 1995."},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200002000-00008"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(89)80253-5"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198902000-00005"},{"key":"e_1_2_7_19_2","first-page":"231","article-title":"The ultrastructure of alveolar and embryonal rhabdomyosarcoma. A correlative and electron microscopic study of 17 cases","volume":"92","author":"Seidal T","year":"1984","journal-title":"Acta Pathol. Microbiol. Immunol. Scand. A"},{"key":"e_1_2_7_20_2","unstructured":"WickMR.Rhabdomyosarcoma of the mediastinum. In Sternberg SS ed.Diagnostic surgical pathology 3rd edn. Philadelphia: Lippincott Williams & Wilkins 1999; 1173\u20131174."},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90142-2"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199107000-00001"},{"key":"e_1_2_7_23_2","first-page":"72","article-title":"A thymoma with clonal complex chromosome abnormalities","volume":"110","author":"Sonobe H","year":"1999","journal-title":"Cancer Genet. Cytogenet."},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931001)72:7<2273::AID-CNCR2820720735>3.0.CO;2-U"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098-2264(199805)22:1<16::aid-gcc3>3.0.co;2-a"},{"key":"e_1_2_7_26_2","first-page":"83","article-title":"A thymic squamous cell carcinoma with complex chromosome abnormalities","volume":"103","author":"Sonobe H","year":"1998","journal-title":"Cancer Genet. Cytogenet."},{"key":"e_1_2_7_27_2","first-page":"2786","article-title":"Chromosome analysis of 31 Wilms\u2019 tumors","volume":"50","author":"Wang\u2010Wuu S","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_7_28_2","first-page":"58","article-title":"Myogenic differentiation in spindle cell (sarcomatoid) carcinomas of the upper aerodigestive tract","volume":"1","author":"Nakhleh R","year":"1993","journal-title":"Appl. Immunohistochem."},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/108.1.40"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199711000-00006"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00691.x"},{"key":"e_1_2_7_32_2","first-page":"19","article-title":"Ultrastructural examination of three cases of malignant thymoma (in Japanese)","volume":"24","author":"Murakami S","year":"1984","journal-title":"Nihon Mounaikei Gakkaishi"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00035"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.1163b.x"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2559.2002.01310.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2559.2002.01310.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2559.2002.01310.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T05:28:11Z","timestamp":1697520491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2559.2002.01310.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1046\/j.1365-2559.2002.01310.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2559.2002.01310.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"2002-01-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}