{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:02:59Z","timestamp":1789642979160,"version":"4.0.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,10,30]],"date-time":"2003-10-30T00:00:00Z","timestamp":1067472000000},"content-version":"vor","delay-in-days":2220,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:p>The transmissible spongiform encephalopathies are neurodegenerative disorders which include Creutzfeldt\u2013Jakob disease in humans, and scrapie and bovine spongiform encephalopathy in animals. A major component of the infectious agent responsible for these diseases is considered to be a post\u2010translationally modified form of a host\u2010encoded glycoprotein PrP<jats:sup>c<\/jats:sup>, termed PrP<jats:sup>Sc<\/jats:sup>. While PrP<jats:sup>c<\/jats:sup> is abundantly expressed in tissues of the central nervous system (CNS), little is known about its normal function. The expression of PrP<jats:sup>c<\/jats:sup> is not restricted to the CNS, as this protein can also be detected in the lymphoid tissues of mice and sheep. In this report we demonstrate that resting murine splenic lymphocytes express PrP<jats:sup>c<\/jats:sup> protein on their cell membranes. Furthermore, expression of PrP<jats:sup>c<\/jats:sup> was significantly enhanced following <jats:italic>in vitro<\/jats:italic> stimulation with the non\u2010specific T\u2010cell mitogen concanavalin A (Con A). Genetically engineered mice with an inactive PrP<jats:sup>c<\/jats:sup> gene (PrP<jats:sup>\u2212\/\u2212<\/jats:sup> mice), were utilized to investigate the involvement of PrP<jats:sup>c<\/jats:sup> in lymphocyte activation. Experiments revealed that the Con A\u2010induced proliferation of lymphocytes from PrP<jats:sup>\u2212\/\u2212<\/jats:sup> mice was significantly reduced to \u224850\u201380% that of wild\u2010type (PrP<jats:sup>+\/+<\/jats:sup>) mice 48\u2003hr post\u2010stimulation. These findings demonstrate an important role for PrP<jats:sup>c<\/jats:sup> in extra\u2010neuronal tissues and suggest that PrP<jats:sup>c<\/jats:sup> is a lymphocyte surface molecule that participates in T\u2010cell activation.<\/jats:p>","DOI":"10.1046\/j.1365-2567.1997.00331.x","type":"journal-article","created":{"date-parts":[[2003,11,2]],"date-time":"2003-11-02T15:48:04Z","timestamp":1067788084000},"page":"161-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["T\u2010lymphocyte activation and the cellular form of the prion protein"],"prefix":"10.1111","volume":"92","author":[{"given":"N. A.","family":"MABBOTT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. L.","family":"BROWN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"MANSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"BRUCE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,30]]},"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2567.1997.00331.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2567.1997.00331.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2567.1997.00331.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T07:14:48Z","timestamp":1694416488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2567.1997.00331.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["10.1046\/j.1365-2567.1997.00331.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2567.1997.00331.x","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]},"assertion":[{"value":"2003-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}