{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:22:38Z","timestamp":1772896958082,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":1242,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:p>In murine <jats:italic>Schistosomiasis mansoni circumovum<\/jats:italic>, granuloma formation is regulated by pro\u2010 and anti\u2010inflammatory cytokines. Among the latter, interleukin\u201010 (IL\u201010) has been shown to regulate the inflammatory response. In this study we examined the role of endogenously produced IL\u201010 in T\u2010helper 1 (Th1)\u2010 and Th2\u2010type cytokine production and granuloma formation. The dynamics of IL\u201010 production through the course of the infection were different in granuloma versus splenic cells. In the former, production peaked during the early developmental stage (6 weeks of infection) of the granuloma and then declined. In splenocytes production peaked at 12 weeks, before down\u2010modulation of the granuloma response. In the developing granuloma both macrophages and T\u2003cells secreted IL\u201010. In anti\u2010IL\u201010 monoclonal antibody (mAb)\u2010supplemented granuloma cell cultures endogenous IL\u201010\u2010mediated regulation of interferon\u2010\u03b3 (IFN\u2010\u03b3) was manifest only at 6 weeks; that of IL\u20102 continued throughout the infection (6\u201320 weeks). IL\u20104 production was unaffected, but IL\u20105 production was regulated at the 6 and 8 weeks time point. Splenocytes showed regulation of IFN\u2010\u03b3 and IL\u20102 production at the peak of the granulomatous response (8 weeks). IL\u20104 production was not regulated, whereas IL\u20105 production was regulated only at 6 weeks. Repeated injections of anti\u2010IL\u201010\u2003mAb given to mice at 6, 12 or 20 weeks of the infection significantly enhanced liver and lung granuloma growth, tissue eosinophilia, and IFN\u2010\u03b3, IL\u20105 production at the early developmental phase (6 weeks) of the lesions. Thus, in schistosome\u2010infected mice endogenous IL\u201010 is shown to regulate Th1\u2010 and Th2\u2010type cytokine production and granuloma formation during the early Th0\/Th1 phase of the immune response.<\/jats:p>","DOI":"10.1046\/j.1365-2567.1998.00544.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T02:19:35Z","timestamp":1047435575000},"page":"481-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Endogenous IL\u201010 regulates IFN\u2010\u03b3 and IL\u20105 cytokine production and the granulomatous response in <i>Schistosomiasis mansoni<\/i>\u2010infected mice"],"prefix":"10.1111","volume":"94","author":[{"family":"BOROS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"WHITFIELD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4049\/jimmunol.128.1.37","article-title":"Delayed hypersensitivity granuloma formation and modulation around Schistosoma mansoni eggs in vitro. 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