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The drugs particularly suppressed the levels of CD83 and the secreted p40 unit of interleukin\u201012 (IL\u201012), both markers of mature dendritic cells; 50% inhibitory concentration (IC<jats:sub>50<\/jats:sub>) values were 2\u00b75\u2003m\n\t\t\t\t\t<jats:sc>m<\/jats:sc>, a concentration more than 100 times greater than the concentration at mid\u2010point inhibition (ID<jats:sub>50<\/jats:sub>) value for inhibition of prostaglandin synthesis. Concomitantly, the levels of CD14, a marker of monocytes\/macrophages, increased above the levels found in immature dendritic cells. Cyclooxygenase inhibitors ketoprofen, indomethacin and NS\u2010398 had no effect at concentrations more than a thousand\u2010fold higher than their IC<jats:sub>50<\/jats:sub> values. The effects were independent of the presence of prostaglandin E<jats:sub>2<\/jats:sub> in the medium. Salicylates suppressed activation of the nuclear transcription factor \u03baB, which regulates dendritic cell differentiation, but their effects on mature dendritic cells were negligible. Hence, aspirin inhibits dendritic cell function by inhibiting their terminal differentiation at concentrations achieved in the blood of patients chronically treated with high\u2010dose aspirin.<\/jats:p>","DOI":"10.1046\/j.1365-2567.2000.00065.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T02:25:38Z","timestamp":1047435938000},"page":"53-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Cyclooxygenase\u2010independent inhibition of dendritic cell maturation by aspirin"],"prefix":"10.1111","volume":"101","author":[{"given":"R.","family":"Matasi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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