{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:41:52Z","timestamp":1759333312201},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":724,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Studies of superantigens (SAg) have focused primarily on their impact on CD4<jats:sup>+<\/jats:sup> T cells, largely bypassing the impact of the sequelae of this interaction upon the antigen\u2010presenting cell (APC). Sequelae of SAg\u2010induced CD4<jats:sup>+<\/jats:sup> T\u2010cell activation include the \u2018bathing\u2019 of the SAg\u2010presenting cell with cytokines that promote the differentiation of the APC. In this report, the SAg\u2010induced differentiation of Mls<jats:sup>+<\/jats:sup> DBA\/2J B cells was studied <jats:italic>in vivo<\/jats:italic> by their transplantation into B\u2010cell\u2010defective BALB.<jats:italic>xid<\/jats:italic> recipients. Rapid, high\u2010level serum immunoglobulin M (IgM) production was noted shortly after transfer, disappearing by 3\u2003weeks. Donor B cells, as evidenced after their chemical and genetic impairment and by the use of an IgM allotype\u2010disparate donor\u2013recipient combination, contributed to this transient IgM production. These results clarify a discrepancy in the literature regarding donor B\u2010cell contribution to IgM production and illustrate a model system to utilize SAg to study B\u2010lymphocyte diversity.<\/jats:p>","DOI":"10.1046\/j.1365-2567.2000.00929.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T02:26:26Z","timestamp":1047435986000},"page":"147-152","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["DBA\/2J (Mls\u20101<sup>a<\/sup>) B\u2010cell differentiation in BALB.<i>xid<\/i> recipients"],"prefix":"10.1111","volume":"99","author":[{"given":"K.","family":"Tocce","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Suppiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Rago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Liberchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Riggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2567.2000.00929.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2567.2000.00929.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2567.2000.00929.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T10:46:38Z","timestamp":1698576398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2567.2000.00929.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1046\/j.1365-2567.2000.00929.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2567.2000.00929.x","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"2001-12-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}