{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:50:03Z","timestamp":1790866203393,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":2595,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mice lacking the suppressor of cytokine signalling\u20101 (SOCS1) die within weeks of birth with extensive fatty degeneration of the liver, consistent with acute hepatic toxicity to interferon\u2010\u03b3 (IFN\u2010\u03b3), and inflammation of multiple organs. We show here that treatment for 1\u2003week from birth with neutralizing antibody to IFN\u2010\u03b3 rescues SOCS1<jats:sup>\u2212\/\u2212<\/jats:sup> mice from lethal liver disease but the mice subsequently succumb to chronic inflammatory lesions characterized by T\u2010lymphocyte infiltration of skeletal muscle, pancreas, lung, liver and skin. Elevated blood levels of eosinophils, neutrophils and platelets were also observed and the thymic lymphocyte population was depleted of CD4<jats:sup>+<\/jats:sup>\u2003CD8<jats:sup>+<\/jats:sup> T cells and showed a reduced CD4\u200a:\u200aCD8 ratio. All T\u2010cell populations in thymus, spleen and lymph node exhibited an increased proportion of cells bearing the activation marker CD44. These data suggest an important role for SOCS1 in T\u2010lymphocyte regulation.<\/jats:p>","DOI":"10.1046\/j.1365-2567.2001.01294.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T02:29:48Z","timestamp":1047436188000},"page":"92-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Neutralization of interferon\u2010\u03b3 in neonatal SOCS1<sup>\u2212\/\u2212<\/sup> mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease"],"prefix":"10.1111","volume":"104","author":[{"given":"Denise V. 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