{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:00:56Z","timestamp":1793152856573,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,4,24]],"date-time":"2002-04-24T00:00:00Z","timestamp":1019606400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Insect Molecular Biology"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    One way of controlling disease transmission by blood\u2010feeding mosquitoes is to reduce the frequency of insect\u2013host interaction, thus reducing the probability of parasite transmission and re\u2010infection. A better understanding of the olfactory processes responsible for allowing mosquitoes to identify human hosts is required in order to develop methods that will interfere with host seeking. We have therefore initiated a molecular approach to isolate and characterize the genes and their products that are involved in the olfactory recognition pathway of the mosquito\n                    <jats:italic>Anopheles gambiae,<\/jats:italic>\n                    which is the main malaria vector in sub\u2010Saharan Africa. We report here the isolation and preliminary characterization of several cDNAs from male and female\n                    <jats:italic>A. gambiae<\/jats:italic>\n                    antennal libraries that encode putative odourant binding proteins. Their conceptual translation products show extensive sequence similarity to known insect odourant binding proteins (OBPs)\/pheromone binding proteins (PBPs), especially to those of\n                    <jats:italic>D. melanogaster.<\/jats:italic>\n                    The\n                    <jats:italic>A. gambiae<\/jats:italic>\n                    OBPs described here are expressed in the antennae of both genders, and some of the\n                    <jats:italic>A. gambiae<\/jats:italic>\n                    OBP genes are well conserved in other disease\u2010transmitting mosquito species, such as\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    and\n                    <jats:italic>Culex quinquefasciatus.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1046\/j.1365-2583.2002.00316.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T21:12:21Z","timestamp":1047417141000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Isolation of cDNA clones encoding putative odourant binding proteins from the antennae of the malaria\u2010transmitting mosquito,\n                    <i>Anopheles gambiae<\/i>"],"prefix":"10.1111","volume":"11","author":[{"given":"Harald","family":"Biessmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika F.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiros","family":"Dimitratos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5461.2185"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/143.1.293"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.4.1516"},{"key":"e_1_2_6_6_1","first-page":"380","article-title":"White eye, a new sex\u2010linked mutant of Aedes aegypti","volume":"28","author":"Bhalla S.C.","year":"1968","journal-title":"Mosquito News"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2583.1998.71054.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0020-1790(90)90088-C","article-title":"A novel class of binding proteins in the antennae of the silk moth Antheraea perneyi","volume":"20","author":"Breer H.","year":"1990","journal-title":"Insect Biochem"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(96)10015-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2583.2000.00176.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81093-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.1996.tb00742.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00182a009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00027a023"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(97)00012-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2583.2000.00221.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.en.40.010195.002303"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5894"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1128\/aem.63.3.1095-1101.1997","article-title":"Influence of exposure to single versus multiple toxins of Bacillus thuringiensis subsp. israelensis on development of resistance in the mosquito Culex quinquefasciatus (Diptera: Culicidae)","volume":"63","author":"Georghiou G.P.","year":"1997","journal-title":"Appl Environ, Microbiol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(92)90216-Y"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(00)00177-6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.24.9851"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/genetics\/155.1.117","article-title":"Molecular evolution of odorant\u2010binding protein genes OS\u2010E and OS\u2010F in Drosophila","volume":"155","author":"Hekmat\u2010Scafe D.S.","year":"2000","journal-title":"Genetics"},{"key":"e_1_2_6_24_1","volume-title":"Olfaction in Mosquito\u2013Host Interactions. 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