{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T05:01:23Z","timestamp":1794373283569,"version":"4.9.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":418,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to examine the effect of undiluted NaOCl on vital pulp tissue when applied to freshly cut dentine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Class V cavities were prepared to a depth of 2\u00a0mm in 20 teeth in four Beagle dogs. The cavities on one side of each dog were irrigated continuously for 5\u00a0min with 5.25% NaOCl, whilst the cavities on the opposite side in each dog were irrigated with saline for the same length of time. Prior to filling each cavity with Cavit, they were again rinsed with saline and gently dried with an air stream. The dogs were sacrificed to allow for investigation of pulpal conditions under the cavities after periods of 24\u00a0h, 1\u00a0week, and 4\u00a0weeks. Histological preparations were made and stained with H &amp; E for evaluation of the pulp subjacent to each cavity. The tissues were examined for presence of inflammatory cells and categorized as (i) no inflammation, (ii) mild, (iii) moderate, and (iv) severe inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The six teeth in the 24\u00a0h observation group all showed mild inflammation, both in the NaOCl and the saline groups. After 1\u00a0week and 4\u00a0weeks, the pulps from all the teeth were free of inflammatory cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Under the conditions of this experiment, the use of NaOCl in a freshly cut cavity in an intact tooth of a dog, with exposed dentinal tubules, does not appear to cause additional pulpal damage to that caused by the physical contact in cutting tooth structure.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2591.2000.00348.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T00:49:44Z","timestamp":1047430184000},"page":"505-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pulpal response to prolonged dentinal exposure to sodium hypochlorite"],"prefix":"10.1111","volume":"33","author":[{"given":"H.\u2010M.","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nordb\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. K.","family":"Bakland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"387","article-title":"The dentin: a barrier to caries","volume":"109","author":"Bradford EW","year":"1960","journal-title":"British Dental Journal"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016513"},{"key":"e_1_2_5_4_1","first-page":"181","volume-title":"Endodontics","author":"Ingle JI","year":"1994"},{"key":"e_1_2_5_5_1","first-page":"1061","article-title":"Decalcification of artificially decalcified dentin in vivo","volume":"49","author":"Koto S","year":"1970","journal-title":"Journal of Dental Research"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345760550062901"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(59)90227-0"},{"key":"e_1_2_5_8_1","first-page":"67","article-title":"Chemical treatment of cavity walls following manual excavation of carious dentin","volume":"9","author":"Nordb\u00f6 H","year":"1996","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345750540050301"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(85)80197-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(78)90099-3"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(78)80129-0"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1959.0125"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(68)90312-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(68)90045-5"},{"key":"e_1_2_5_16_1","first-page":"270","article-title":"Effectiveness of caries removal by the partial tunnel preparation method","volume":"101","author":"Strand GV","year":"1993","journal-title":"Scandinavian Journal of Dental Research"},{"key":"e_1_2_5_17_1","first-page":"151","article-title":"Variation among operators in the performance of tunnel preparations in vitro","volume":"102","author":"Strand GV","year":"1994","journal-title":"Scandinavian Journal of Dental Research"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.1990.tb04680.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1971.0068"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(95)91182-M"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2591.2000.00348.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2591.2000.00348.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T10:43:33Z","timestamp":1698576213000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2591.2000.00348.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["10.1046\/j.1365-2591.2000.00348.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2591.2000.00348.x","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]},"assertion":[{"value":"2001-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}