{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:31:26Z","timestamp":1773293486946,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"vor","delay-in-days":173,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate pigmentation and tissue response to four endodontic sealers placed in the oral mucosa of rabbits by either submucous injection or implant in polyethylene tubes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Thirty white New Zealand rabbits were divided randomly into two groups of eight for N\u2010Rickert and AH\u201026, and two groups of seven for Fillcanal and Sealer 26. On the right side of the filter, corresponding to the gingivo\u2010labial sulcus in humans, the sealer was injected; on the left side the sealer was placed within a polyethylene tube and implanted. Direct clinical observations were made at 30, 60 and 90\u00a0days. The animals were then sacrificed for histological analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 60\u00a0days of observation N\u2010Rickert and AH\u201026 produced tattoos that became larger by 90\u00a0days. Submucous injection produced larger and more numerous pigmentation, when compared to implant in polyethylene tubes. N\u2010Rickert sealer displayed larger and more numerous tattoos when compared to AH\u201026. Histological analysis showed no differences between the two methods of implantation. All sealers elicited some kind of inflammatory response; the most irritant was Fillcanal, followed by N\u2010Rickert and AH\u201026. Sealer 26 elicited a mild reaction only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Under the conditions of this study there was no relationship between the method of implantation and the tissue response; the silver\u2010containing sealers produced pigmentation, and the concentration of silver influenced the quantity and size of the tattoos. The sealers elicited various responses when in direct contact with the surrounding tissues; the calcium hydroxide\u2010containing sealer had enhanced healing when compared to the other sealers.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2591.2001.00407.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T00:50:39Z","timestamp":1047430239000},"page":"377-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The histological effects of four endodontic sealers implanted in the oral mucosa: submucous injection versus implant in polyethylene tubes"],"prefix":"10.1111","volume":"34","author":[{"given":"J. A. P.","family":"Figueiredo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. F.","family":"Pesce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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