{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:56:18Z","timestamp":1791888978774,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,1,25]],"date-time":"2002-01-25T00:00:00Z","timestamp":1011916800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Aim<\/jats:bold>\n                    The purpose of this study was to investigate the levels of substance P (SP), neurokinin A (NKA) and calcitonin gene\u2010related peptide (CGRP) in painful and healthy human dental pulps.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methodology<\/jats:bold>\n                    Forty\u2010six samples of pulp tissue were collected from extracted or endodontically treated painful teeth and 20 from clinically healthy teeth extracted for orthodontic reasons. All pulp samples were boiled in 0.5\u00a0m acetic acid for 10\u00a0min, centrifuged and the supernatant collected. SP, NKA and CGRP levels were measured using radioimmunoassay.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    Substance P and CGRP were present in all samples and NKA was detected in 96% of the pulps. CGRP was present in much higher concentrations than SP and NKA in both painful and non\u2010painful teeth. The painful teeth had significantly higher concentrations of SP (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.02), NKA (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and CGRP (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.03) than non\u2010painful teeth. The concentration of CGRP was significantly higher in the pulps of smokers compared with non\u2010smokers (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.02).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    Elevated levels of these neuropeptides in pulps from painful teeth indicate that they may play an important role in the process of pulpal inflammation and pain. Further investigation of the association between these neuropeptides and pulpal status may help to improve our understanding of pulpal inflammation and dental pain.\n                  <\/jats:p>","DOI":"10.1046\/j.1365-2591.2002.00451.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T19:51:21Z","timestamp":1047412281000},"page":"30-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Quantitative analysis of substance P, neurokinin A and calcitonin gene\u2010related peptide in pulp tissue from painful and healthy human teeth"],"prefix":"10.1111","volume":"35","author":[{"given":"L.","family":"Awawdeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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