{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T15:44:36Z","timestamp":1762443876911},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,3,19]],"date-time":"2002-03-19T00:00:00Z","timestamp":1016496000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim<\/jats:bold> To describe some toxic effects of arsenic trioxide in the mouth, to condemn its continued use, and present a case in which a tooth was preserved despite significant bony destruction.<\/jats:p><jats:p><jats:bold>Summary<\/jats:bold> A case is presented in which severe alveolar bone necrosis resulted from leakage of an arsenical devitalization paste into the periodontium.<\/jats:p><jats:p>The tooth was root canal treated before root amputation, and restored with a cuspal coverage restoration. The tooth was observed to be symptomless and functional at the one\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key learning points<\/jats:title><jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Arsenic and its compounds have no place in contemporary endodontics.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Dentists should protect their patients by avoiding the use of arsenic\u2010containing materials and refusing to use products whose constituents are not known.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Localized bone necrosis may not require tooth extraction. Depending on the severity of the case, the tooth may be preserved by a combination of endodontic, periodontal, prosthodontic and maintenance therapies.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2591.2002.00491.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T00:51:42Z","timestamp":1047430302000},"page":"295-299","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Localized alveolar bone necrosis following the use of an arsenical paste: a case report"],"prefix":"10.1111","volume":"35","author":[{"given":"N.","family":"\u00d6zmeri\u00e7","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,3,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1997.00105.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1998.tb00837.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1994.tb00240.x"},{"key":"e_1_2_5_5_1","first-page":"174","article-title":"Phosphorus necrosis of the maxilla","volume":"38","author":"Jakhi SA","year":"1983","journal-title":"Journal of Oral Medicine"},{"key":"e_1_2_5_6_1","first-page":"1236","article-title":"Furcation involvements: therapeutic considerations","volume":"19","author":"Kim Y","year":"1998","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_5_7_1","volume-title":"Developments in Occupational Medicine","author":"Nagle G","year":"1980"},{"key":"e_1_2_5_8_1","first-page":"263","article-title":"Tissue necrosis after using an arsenical endodontic preparation: a case report","volume":"24","author":"Smart ER","year":"1991","journal-title":"International Endodontic Journal"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(83)80107-1"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(85)80058-6"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2591.2002.00491.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2591.2002.00491.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T19:16:46Z","timestamp":1697570206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2591.2002.00491.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1046\/j.1365-2591.2002.00491.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2591.2002.00491.x","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]},"assertion":[{"value":"2002-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}