{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:01:44Z","timestamp":1789203704112,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2775,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>\n                    <jats:italic>Objectives<\/jats:italic>\n                    . The aim of this study was to investigate the morphological appearance of severe hypomineralized enamel of permanent first molars by means of polarized light microscopy, and to estimate the possible time, severity and longevity of the insult. Furthermore, the aim was to survey some commonly implicated aetiological factors in order to gain knowledge about possible pathogenesis of the enamel disturbances which could be compared with future epidemiological studies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Sample and methods<\/jats:italic>\n                    . Seventy\u2010three teeth, which had been extracted due to severe hypomineralizations of the enamel, were collected and serially cut longitudinally in a bucco\u2010lingual direction. The sections were examined in polarized light, dry and embedded in water. The children were also examined with respect to the demarcated opacities of other permanent teeth than those that were extracted. The parents were asked about their health during the mother\u2019s pregnancy, the time of gestation, birth weight and any complications. They were also asked about the child\u2019s health during the first 2 years of its life, the length of time of breast\u2010feeding and also about fluoride supplements.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    . The hypomineralized areas extended cervically from the cusps, comprising about half of the buccal and lingual sides. The cervical borders to normal enamel were well defined and mainly followed the lines of Hunter\u2010Schreger. The hypomineralized zones were covered by thin well\u2010mineralized enamel. The majority of the children had demarcated opacities of all their first molars and also of some permanent incisors. No obvious correlation to the anamnestic data could be found.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . The hypomineralized enamel in the investigated teeth demonstrated areas of porosity of varying degrees. The yellow\/brown defects were more porous than the white\u2010cream and extended through the whole enamel layer, while the white\u2010cream opacities were situated in the inner parts of the enamel. There had probably been an interacting disturbance of short duration of systemic origin of the activity of the ameloblast during the first 2 years of the child\u2019s life, resulting in chronological dispersed hypomineralized demarcated opacities in the developing teeth.\n                  <\/jats:p>","DOI":"10.1046\/j.1365-263x.2000.00210.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T21:43:49Z","timestamp":1047419029000},"page":"278-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":249,"title":["Enamel hypomineralization of permanent first molars: a morphological study and survey of possible aetiological factors"],"prefix":"10.1111","volume":"10","author":[{"given":"B.","family":"J\u00e4levik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.","family":"Nor\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"KochG Mode\u00e9rT PoulsenS&RasmussenP eds.Pedodontics. A systematic approach.Copenhagen: Munksgaard 1991:250\u2013274."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/08959374890030022901"},{"key":"e_1_2_5_4_2","unstructured":"FDI Commission on Oral Health Research and Epidemiology.An epidemiological index of developmental defects of dental enamel (DDE Index).International Dental Journal1982;32:159\u2013167."},{"key":"e_1_2_5_5_2","unstructured":"FDI Commission on Oral Health Research and Epidemiology.A review of the development defects of enamel index (DDE Index).International Dental Journal1992;42:411\u2013426."},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(78)90004-0"},{"key":"e_1_2_5_7_2","first-page":"123","article-title":"Aetiology of developmental enamel defects not related to fluorosis.","volume":"32","author":"Pindborg JJ.","year":"1982","journal-title":"International Dental Journal."},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1941.0307"},{"key":"e_1_2_5_9_2","first-page":"1482","article-title":"Mineraliseringsst\u00f6rningar av speciell typ.","volume":"71","author":"Forsman B.","year":"1979","journal-title":"Tandl\u00e4kartidningen"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1987.tb00538.x"},{"key":"e_1_2_5_11_2","first-page":"266","article-title":"Cheese molars: a pilot study of the etiology of hypocalcifations in first permanent molars.","volume":"4","author":"Van Amerongen WE","year":"1995","journal-title":"Journal of Dentistry for Children"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1996.tb00131.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/1382-6689(96)00007-5"},{"key":"e_1_2_5_14_2","first-page":"49","article-title":"Cutting of mineralized hard tissues with the Leitz low\u2010speed saw microtome.","volume":"9","author":"Nor\u00e9n JG","year":"1987","journal-title":"Leitz Mitteilungen"},{"key":"e_1_2_5_15_2","first-page":"361","article-title":"A morphologic investigation of certain variation in the structure and mineralization of human enamel.","volume":"67","author":"Gustavsson AG.","year":"1959","journal-title":"Odontologiska Tidskrift"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(62)90022-5"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/08959374890030022301"},{"key":"e_1_2_5_18_2","unstructured":"FejerskovO EkstrandJ&BurtBA eds.Fluoride in dentistry. Copenhagen: Munksgaard 1996:112\u2013152."},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690S138"},{"key":"e_1_2_5_20_2","unstructured":"1986:204\u2013234."},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1984.tb01434.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660091101"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345800590092701"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/08959374890030021901"},{"key":"e_1_2_5_25_2","first-page":"1532","article-title":"Progressive mineralization pattern of developing enamel during maturation stage.","volume":"61","author":"Suga S.","year":"1982","journal-title":"Journal of Dental Research"},{"key":"e_1_2_5_26_2","unstructured":"SugaS.Comparative histology of the progressive mineralization pattern of developing enamel.In: Suga (ed.)Mechanism of Tooth Enamel Formation. Tokyo: Quintessence Publishing Co. 1983:167\u2013203."},{"key":"e_1_2_5_27_2","first-page":"1153","article-title":"The development of human dentition.","volume":"28","author":"Schour I","year":"1941","journal-title":"Journal of American Dental Association"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345630420062701"}],"container-title":["International Journal of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-263x.2000.00210.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-263x.2000.00210.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T09:17:15Z","timestamp":1698571035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-263x.2000.00210.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["10.1046\/j.1365-263x.2000.00210.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-263x.2000.00210.x","archive":["Portico"],"relation":{},"ISSN":["0960-7439","1365-263X"],"issn-type":[{"value":"0960-7439","type":"print"},{"value":"1365-263X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12]]},"assertion":[{"value":"2008-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}