{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:04:00Z","timestamp":1764259440139},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":572,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p><jats:bold>Abstract.<\/jats:bold> Pick N, Potasman I, Strenger C, Keysary A, Schwartz I (Bnai Zion Medical Center, and Technion Faculty of Medicine, Haifa; Israel Institute for Biological Research, Ness\u2010Ziona, Israel; New York Medical College, USA). Ehrlichiosis associated vasculitis. <jats:italic>J   Intern   Med<\/jats:italic> 2000; <jats:bold>247<\/jats:bold>: 674\u2013678.<\/jats:p><jats:p><jats:bold>Objective.<\/jats:bold> To test the hypothesis that some cases of primary vasculitis are caused by ehrlichiosis.<\/jats:p><jats:p><jats:bold>Design.<\/jats:bold> A retrospective case study and serological analysis of stored sera.<\/jats:p><jats:p><jats:bold>Setting.<\/jats:bold> University hospital.<\/jats:p><jats:p><jats:bold>Subjects.<\/jats:bold> Fifty\u2010five patients discharged with any type of vasculitis over a 6\u2010year period.<\/jats:p><jats:p><jats:bold>Main outcome measures.<\/jats:bold> Serology for human monocytic ehrlichiosis, and the human granulocytic ehrlichiosis agent, and polymerase chain reaction (PCR) analysis of biopsy specimens.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Three patients (5.5%) had titres of 1\u2003:\u2003128 or higher against <jats:italic>E. chaffeensis;<\/jats:italic> none was positive for the human granulocytic ehrlichiosis agent. Skin biopsies of these patients showed lesions compatible with polyarteritis nodosa, allergic purpura and unspecified vasculitis. PCR analysis of the biopsies was unrevealing.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Infection with human monocytic ehrlichiosis may underlie some forms of vasculitis. If confirmed, these findings may help identify patients with vasculitis who would benefit from antibiotic treatment.<\/jats:p>","DOI":"10.1046\/j.1365-2796.2000.00680.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T06:11:51Z","timestamp":1047449511000},"page":"674-678","source":"Crossref","is-referenced-by-count":8,"title":["Ehrlichiosis associated vasculitis"],"prefix":"10.1111","volume":"247","author":[{"given":"N.","family":"Pick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Potasman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Strenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Keysary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1910","volume-title":"Harrison\u2019s Principles of Internal Medicine 14 Ed, Vol 2","author":"Fauci A.","year":"1998"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197601000-00001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.5.334"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211193272104"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.4.1010"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-9-199405010-00002"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.5.1102"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.4.821"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1128\/jcm.35.6.1510-1516.1997","article-title":"An indirect immunofluorescent assay using a cell culture\u2010derived antigen for detection of antibodies to the agent of human granulocytic ehrlichiosis.","volume":"35","author":"Nicholson W","year":"1997","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1997.56.339"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1128\/jcm.35.8.2087-2092.1997","article-title":"PCR amplification and comparison of nucleotide sequences from the groESL heat shock operon of Ehrlichia species.","volume":"35","author":"Sumner J","year":"1997","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412153312410"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.138.11.257"},{"key":"e_1_2_5_15_2","unstructured":"KeysaryA AmramL RzotkiewiczS StrengerC WanerT.The diagnosis of rickettsial diseases in Israel. 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