{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:01:55Z","timestamp":1790514115491,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":572,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p><jats:bold>Abstract.<\/jats:bold> Airaghi L, Montori D, Santambrogio L, Miadonna A, Tedeschi A (IRCCS Ospedale Maggiore Policlinico, Milan, Italy). Chronic systemic capillary leak syndrome. Report of a case and review of the literature (Case Report). <jats:italic>J Intern Med<\/jats:italic> 2000; <jats:bold>247:<\/jats:bold> 731\u2013735.<\/jats:p><jats:p>Systemic capillary leak syndrome (SCLS) is a rare condition characterized by recurrent episodes of generalized oedema and severe hypotension, associated with paraproteinaemia. In addition to the acute form, a few cases of chronic SCLS have been reported. We describe a 64\u2010year\u2010old woman who was hospitalized because of a 6\u2010month history of progressive generalized oedema with pericardial and pleural effusions, associated with a serum paraprotein. Clinical and laboratory findings were consistent with a chronic form of SCLS. Treatment with prednisone, furosemide and theophylline was started, which led to a gradual improvement in 2\u2003weeks and a persistent remission after 9\u2003months. This report indicates that SCLS may occur in a chronic form, which seems to be responsive to a therapeutic regimen with prednisone, furosemide, and theophylline.<\/jats:p>","DOI":"10.1046\/j.1365-2796.2000.00693.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T06:11:51Z","timestamp":1047449511000},"page":"731-735","source":"Crossref","is-referenced-by-count":34,"title":["Chronic systemic capillary leak syndrome. 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