{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:53:31Z","timestamp":1761893611044},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":450,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p><jats:bold>Abstract.<\/jats:bold> Krebs T, Zimmerli S, Bodmer T &amp; L\u00e4mmle B (Central Hematology Laboratory, Inselspital, University Hospital of Bern; Institute of Medical Microbiology, University of Bern, Bern, Switzerland). <jats:italic>Mycobacterium genavense<\/jats:italic> infection in a patient with long\u2010standing chronic lymphocytic leukaemia (Case Report). <jats:italic>J Intern Med<\/jats:italic> 2000; <jats:bold>248:<\/jats:bold> 343\u2013348.<\/jats:p><jats:p>We describe the first case of disseminated infection with <jats:italic>Mycobacterium genavense<\/jats:italic> in an HIV\u2010seronegative patient with a chronic haematological disorder. Our patient, an 80\u2010year\u2010old woman, had been under long\u2010term treatment with chlorambucil (partially in combination with prednisone) for B\u2010cell chronic lymphocytic leukaemia (B\u2010CLL). When she developed general fatigue and progressive anaemia, as well as progressive lymphadenopathy and splenomegaly, bone marrow biopsy revealed granulomas with acid\u2010fast bacilli, and cultures of both bone marrow and blood grew <jats:italic>M. genavense<\/jats:italic>. The patient\u2019s CD4<jats:sup>+<\/jats:sup> cell count was approximately 100\u2003\u00b5L<jats:sup>\u20131<\/jats:sup>. Treatment with clarithromycin, ethambutol and rifabutin resulted in improvement of anaemia and general health as well as in regression of lymphadenopathy and splenomegaly.<\/jats:p>","DOI":"10.1046\/j.1365-2796.2000.00730.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T06:12:31Z","timestamp":1047449551000},"page":"343-348","source":"Crossref","is-referenced-by-count":31,"title":["<i>Mycobacterium genavense<\/i> infection in a patient with long\u2010standing chronic lymphocytic leukaemia"],"prefix":"10.1111","volume":"248","author":[{"given":"T.","family":"Krebs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zimmerli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bodmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"L\u00e4mmle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02111494"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90397-L"},{"key":"e_1_2_4_4_2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1001\/archinte.1995.00430040074009","article-title":"Clinical and epidemiologic features of infection with Mycobacterium genavense.","volume":"155","author":"Pech\u00e8re M","year":"1995","journal-title":"Arch Intern Med"},{"key":"e_1_2_4_5_2","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1128\/JCM.37.12.3901-3905.1999","article-title":"Disseminated infection with Mycobacterium genavense: a challenge to physicians and mycobacteriologists.","volume":"37","author":"\u00d8stergaard Thomsen V","year":"1999","journal-title":"J Clin Microbiol"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01997055"},{"key":"e_1_2_4_7_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1128\/jcm.31.2.175-178.1993","article-title":"Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis.","volume":"31","author":"Telenti A","year":"1993","journal-title":"J Clin Microbiol"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8479(95)90562-6"},{"key":"e_1_2_4_9_2","first-page":"62","article-title":"Disseminated Mycobacterium genavense infection in a patient with acquired immunodeficiency syndrome: first case report in Taiwan.","volume":"98","author":"Yan JJ","year":"1999","journal-title":"J Formos Med Assoc"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1128\/jcm.34.7.1840-1842.1996","article-title":"Mycobacterium genavense infections in pet animals.","volume":"34","author":"Kiehn TE","year":"1996","journal-title":"J Clin Microbiol"},{"key":"e_1_2_4_11_2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1128\/jcm.34.2.319-323.1996","article-title":"Mycobacteriosis caused by Mycobacterium genavense in birds kept in a zoo: 11\u2010year survey.","volume":"34","author":"Portaels F","year":"1996","journal-title":"J Clin Microbiol"},{"key":"e_1_2_4_12_2","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1128\/jcm.33.9.2514-2515.1995","article-title":"Species\u2010specific Mycobacterium genavense DNA in intestinal tissues of individuals not infected with human immunodeficiency virus.","volume":"33","author":"Dumonceau JM","year":"1995","journal-title":"J Clin Microbiol"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105093241906"},{"key":"e_1_2_4_14_2","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1128\/jcm.30.12.3206-3212.1992","article-title":"Laboratory aspects of Mycobacterium genavense, a proposed species isolated from AIDS patients.","volume":"30","author":"Coyle MB","year":"1992","journal-title":"J Clin Microbiol"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-43-4-841"},{"key":"e_1_2_4_16_2","first-page":"173","volume-title":"Diagnostic Molecular Microbiology.","author":"Kirschner P","year":"1993"},{"key":"e_1_2_4_17_2","first-page":"5362","article-title":"Atypical mycobacteria. 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