{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T22:56:18Z","timestamp":1765666578303},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":450,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Internal Medicine"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p><jats:bold>Abstract.<\/jats:bold> Uddenfeldt P, Danielsson \u00c5 (County Hospital G\u00e4vle and University Hospital Ume\u00e5, Sweden). Primary biliary cirrhosis: survival of a cohort followed for 10\u2003years. <jats:italic>J Intern Med<\/jats:italic> 2000; <jats:bold>248:<\/jats:bold> 292\u2013298.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> To study the natural course of primary biliary cirrhosis (PBC) in order to be able to design accurate clinical pharmacological studies and evaluate the need for liver transplantation.<\/jats:p><jats:p><jats:bold>Design.<\/jats:bold> A cohort of 86 patients with PBC living in northern Sweden was followed for a 10\u2010year period during 1983\u201393. No patients received therapy with ursodeoxy cholic acid or other drugs during the follow\u2010up period.<\/jats:p><jats:p><jats:bold>Method.<\/jats:bold> At start all patients were investigated personally by the authors. At follow\u2010up medical notes were scrutinized and special questionnaires to the current responsible physician were applied. End\u2010points were the time of dropout, liver transplantation, death or end of the study period.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> At follow\u2010up data were available for 84 patients (97%). During the study period 34 patients died, of whom 28 were symptomatic; 15 deaths had no direct connection to PBC. Nineteen deaths were related to PBC of whom two were asymptomatic, the most common cause being end\u2010stage liver disease with liver coma. During the study period in all eight patients were subjected to liver transplantation.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> The survival rate of the 32 asymptomatic PBC patients at the start of the study \n\t\t\t\t\twas the same as a sex\u2010 and age\u2010matched standard background population. Those patients with symptomatic PBC from the beginning of study had a survival rate at 10\u2003years of 50%, and the most ominous sign was a bilirubin greater than 35\u2003\u00b5mol \n\t\t\t\t\t<jats:sc>L<\/jats:sc><jats:sup>\u22121<\/jats:sup>. Liver transplantation was performed in almost 10% in this cohort until 1993. Since then, the indications and referral practice for liver transplantation has changed and is now higher.<\/jats:p>","DOI":"10.1046\/j.1365-2796.2000.00733.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T06:12:31Z","timestamp":1047449551000},"page":"292-298","source":"Crossref","is-referenced-by-count":13,"title":["Primary biliary cirrhosis: survival of a cohort followed for 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