{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T08:42:19Z","timestamp":1698655339299},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,24]],"date-time":"2001-12-24T00:00:00Z","timestamp":1009152000000},"content-version":"vor","delay-in-days":571,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p>Several lines of evidence suggest that one of the mechanisms by which the hypothalamic neuropeptide Y plays an obligatory role in the preovulatory luteinizing hormone (LH) discharge in young rats is to potentiate the action of LH\u2010releasing hormone (LHRH) on LH release at the level of the pituitary. This study examined whether an alteration in the potentiating action of neuropeptide Y on LHRH\u2010induced LH release may contribute to the attenuation or absence of LH surges during female reproductive ageing. Young regularly cycling (2\u20133\u2010month\u2010old) and old constant oestrous (19\u201320\u2010month\u2010old) rats ovariectomized for 7 days were primed with oestradiol\u201017<jats:italic>\u03b2<\/jats:italic>\u2010filled Silastic capsules. Two days later, rats received s.c. progesterone at 09.00\u2003h and then were injected i.p. with either saline or pentobarbital at 13.30 hours. Pentobarbital\u2010treated rats received i.v. pulses of neuropeptide Y, LHRH, a combination of neuropeptide Y and LHRH, or saline, every 30\u2003min from 14.00 to 18.00\u2003h via a jugular cannula. Hourly blood samples were collected between 11.00 and 21.00\u2003h. In old rats, the progesterone\u2010induced LH surge was significantly attenuated and delayed as compared to that of young rats. Pentobarbital injection completely blocked the LH surge. Neuropeptide Y pulses alone had no significant effect on LH release. In contrast, LHRH pulses increased LH release in both age groups, although the response was significantly reduced in older rats. While combined pulses of neuropeptide Y and LHRH significantly increased LH release in both young and old rats as compared to that of LHRH alone, the potentiating action of neuropeptide Y on LHRH\u2010induced LH release remained unchanged between the two age groups. These results, together with our recent demonstration of altered hypothalamic neuropeptide Y neuronal activity in middle\u2010aged pro\u2010oestrous rats, suggest that a deficit in neuropeptide Y secretion and action in the hypothalamus, rather than a decrease in pituitary responsiveness to neuropeptide Y, may partially be responsible for the absence of LH surges in old rats.<\/jats:p>","DOI":"10.1046\/j.1365-2826.2000.00480.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T07:08:37Z","timestamp":1047452917000},"page":"495-500","source":"Crossref","is-referenced-by-count":4,"title":["Evidence Suggesting that the Potentiating Action of Neuropeptide Y on Luteinizing Hormone (LH)\u2010Releasing Hormone\u2010Induced LH Release Remains Unaltered in Aged Female Rats"],"prefix":"10.1111","volume":"12","author":[{"given":"A.","family":"Sahu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Vom SaalFS&FinchCE Reproductive senescence. 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