{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:27:32Z","timestamp":1791271652721,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2685,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Granule cells in the rat dentate gyrus contain mineralocorticoid and glucocorticoid receptors to which the adrenal hormone corticosterone binds with differential affinity. These cells also express various receptor\u2010subtypes for serotonin (5\u2010HT), including the 5\u2010HT<jats:sub>1A<\/jats:sub> receptor which mediates a membrane hyperpolarization accompanied by a decrease in membrane resistance. Earlier studies have shown that removal of corticosterone by adrenalectomy, particularly in the dentate gyrus, results in enhanced expression of the 5\u2010HT<jats:sub>1A<\/jats:sub> receptor mRNA and increased 5\u2010HT<jats:sub>1A<\/jats:sub> receptor binding capacity. This was normalized by activation of mineralocorticoid receptors or concurrent activation of both receptor types. In the present, intracellular recording study <jats:italic>in vitro<\/jats:italic>, we examined if the altered levels of 5\u2010HT<jats:sub>1A<\/jats:sub> receptor mRNA and protein are associated with changes in the response to 5\u2010HT. We found that the hyperpolarization and resistance decrease induced in granule cells by a submaximal (10\u2003\u00b5<jats:sc>M<\/jats:sc>) dose of 5\u2010HT were unaltered 2\u20134\u2003days after adrenalectomy, indicating a dissociation between corticosteroid actions on 5\u2010HT<jats:sub>1A<\/jats:sub> receptor mRNA\/protein levels and functional responses to 5\u2010HT. Subsequent occupation of mineralocorticoid receptors <jats:italic>in vitro<\/jats:italic> significantly suppressed the 5\u2010HT induced change in resistance, 1\u20134\u2003h after steroid application. Compared to this, concurrent activation of glucocorticoid receptors led to large responses to 5\u2010HT. This modulation by steroids was not observed with a higher dose of 5\u2010HT (30\u2003\u00b5<jats:sc>M<\/jats:sc>). The data suggest that with moderate amounts of 5\u2010HT, corticosteroids affect the information flow through the dentate gyrus such that excitatory transmission is promoted with predominant mineralocorticoid receptor activation and attenuated with additional glucocorticoid receptor occupation.<\/jats:p>","DOI":"10.1046\/j.1365-2826.2001.00616.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T07:10:02Z","timestamp":1047453002000},"page":"233-238","source":"Crossref","is-referenced-by-count":14,"title":["Corticosteroid Effects on Serotonin Responses in Granule Cells of the Rat Dentate Gyrus"],"prefix":"10.1111","volume":"13","author":[{"given":"Y. J. G.","family":"Karten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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