{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:01:12Z","timestamp":1774562472861,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T00:00:00Z","timestamp":1222214400000},"content-version":"vor","delay-in-days":2945,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p>Cytosolic pH (pH<jats:sub>i<\/jats:sub>) and the activity of the sodium\u2013proton antiporter (Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> antiporter) were measured in lymphocytes from 22 patients with obstructive sleep apnoea and from 24 age\u2010matched healthy subjects (Controls). The cellular Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> antiporter was measured spectrophotometrically using a pH\u2010sensitive fluorescent dye after intracellular acidification using sodium propionate. Resting pH<jats:sub>i<\/jats:sub> was similar in lymphocytes from patients with obstructive sleep apnoea and from controls (7.36\u2003\u00b1\u20030.20, <jats:italic>n<\/jats:italic>=22; vs. 7.35\u2003\u00b1\u20030.19, <jats:italic>n<\/jats:italic>=24; mean \u00b1\u2003SD). The Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> antiporter activity was significantly higher in patients with obstructive sleep apnoea than in controls (11.87\u2003\u00b1\u20033.26\u2003\u00d7\u200310<jats:sup>\u20133<\/jats:sup> pH<jats:sub>i<\/jats:sub>\/s vs. 4.38\u2003\u00b1\u20031.40\u2003\u00d7\u200310<jats:sup>\u20133<\/jats:sup> pH<jats:sub>i<\/jats:sub>\/s; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). The apparent affinity of the Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> antiporter was not significantly different between the groups (6.90\u2003\u00b1\u20030.23 vs. 6.87\u2003\u00b1\u20030.20). In patients with obstructive sleep apnoea the activity of the Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> antiporter remained stable during the night. The activity of the Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> antiporter was 13.49\u2003\u00b1\u20034.80\u2003\u00d7\u200310<jats:sup>\u20133<\/jats:sup> pH<jats:sub>i<\/jats:sub>\/s at 20.00 and 13.26\u2003\u00b1\u20036.13\u2003\u00d7\u200310<jats:sup>\u20133<\/jats:sup> pH<jats:sub>i<\/jats:sub>\/s at 02.00. From the present results it is concluded that an increased cellular Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> antiporter activity may be a genetic marker for patients who are predisposed to obstructive sleep apnoea.<\/jats:p>","DOI":"10.1046\/j.1365-2869.2000.00207.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T08:59:26Z","timestamp":1047459566000},"page":"285-291","source":"Crossref","is-referenced-by-count":5,"title":["Increased sodium\u2013proton antiporter activity in patients with obstructive sleep apnoea"],"prefix":"10.1111","volume":"9","author":[{"given":"Martin","family":"Tepel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd M.","family":"Sanner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Van Der Giet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Zidek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.2.559"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00447-5"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1681\/ASN.V55s12","article-title":"Acid\u2013base status and intracellular pH regulation in lymphocytes from rats with genetic hypertension","volume":"5","author":"Batlle D.","year":"1994","journal-title":"J. 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