{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:10:58Z","timestamp":1769055058720,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":633,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>Furosemide premedication of horses 4 h prior to exercise significantly attenuates exercise\u2010induced pulmonary capillary hypertension which may help diminish the severity of exercise\u2010induced pulmonary haemorrhage. As pulmonary hemodynamic effects of furosemide may be mediated via a reduction in plasma volume (which is most pronounced 15\u201330 min postfurosemide administration, with plasma volume recovering thereafter), we hypothesized that administration of furosemide at intervals shorter than 4 h before exertion may be more effective in attenuating the exercise\u2010induced rise in pulmonary capillary blood pressure. Thus, our objective was to determine whether furosemide\u2010induced attenuation of exercise\u2010induced pulmonary arterial, capillary and venous hypertension would be enhanced when the drug is administered at intervals shorter than 4 h before exercise. Using established techniques, right atrial, and pulmonary arterial, capillary and wedge (venous) pressures were ascertained in seven healthy, sound, exercise\u2010trained Thoroughbred horses in a randomized split\u2010plot experimental design. Measurements were made at rest and during exercise performed at maximal heart rate (217\u2003\u00b1\u20033 beats\/min) in the control (no medications) experiments and following furosemide administration (250 mg intravenously (i.v.)) at 1, 2, 3 and 4 h before exercise. Sequence of treatments was randomized and 7 days were allowed between experiments on each horse. Although furosemide administration in the four treatment groups caused only insignificant changes in the pulmonary arterial, capillary and wedge pressures of standing horses, furosemide\u2010induced reduction in mean right atrial pressure achieved statistical significance in the 2 h postfurosemide experiments. In the control studies, exercise was attended by statistically significant increments in mean right atrial, as well as pulmonary arterial, capillary and wedge pressures. Although exercise in each of the four furosemide experiments was also attended by significant increments in right atrial as well as pulmonary vascular pressures, in the 1, 2 and 3 h postfurosemide experiments, mean right atrial pressure increased to a significantly lower value than in the control study. Exercise\u2010induced changes in pulmonary vascular pressures in the 1 h postfurosemide experiments were not different from the pressures in the control study. There was a significant attenuation of exercise\u2010induced pulmonary capillary and venous hypertension in the 2, 3 and 4 h postfurosemide experiments, but significant differences among these treatments were not found. Thus, these data did not support the contention that administration of furosemide at intervals shorter than 4 h before exercise is more effective in attenuating exercise\u2010induced pulmonary capillary or venous hypertension in Thoroughbred horses.<\/jats:p>","DOI":"10.1046\/j.1365-2885.2000.00252.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T09:22:14Z","timestamp":1047460934000},"page":"81-89","source":"Crossref","is-referenced-by-count":8,"title":["Pulmonary vascular pressures of Thoroughbred horses exercised 1, 2, 3 and 4 h after furosemide administration"],"prefix":"10.1111","volume":"23","author":[{"family":"Magid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Manohar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Goetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ulbricht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bontkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ghantous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"173","article-title":"Furosemide: practice and politics.","volume":"37","author":"Arthur R.M.","year":"1991","journal-title":"Proceedings of the American Association Equine Practitioners"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1152\/jappl.1982.52.3.634","article-title":"Micro\u2010puncture measurements of lung microvascular pressure during 5\u2010HT infusion.","volume":"52","author":"Bhattacharya J.S.","year":"1982","journal-title":"Journal of Applied Physiology"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7423192"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(94)90029-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1152\/jappl.1997.82.5.1584","article-title":"Very high pressures are required to cause stress failure of pulmonary capillaries in Thoroughbred racehorses.","volume":"92","author":"Birks E.K.","year":"1997","journal-title":"Journal of Applied Physiology"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1992.tb02818.x"},{"key":"e_1_2_6_8_2","first-page":"270","article-title":"Pressures in the right side of the heart and esophagus (pleura) in ponies during strenuous exercise before and after furosemide.","volume":"47","author":"Goetz T.E.","year":"1986","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_9_2","first-page":"1077","article-title":"Selective pulmonary and venous smooth muscle relaxation: a comparison with morphine.","volume":"270","author":"Greenberg S.","year":"1994","journal-title":"Journal of Pharmacological and Experimental Therapeutics"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1991.tb00855.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1998.tb04495.x"},{"key":"e_1_2_6_12_2","unstructured":"Hopper M.K. 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