{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:12:00Z","timestamp":1768464720162,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":633,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>The pharmacokinetics of carprofen, a propionic acid\u2010derived nonsteroidal anti\u2010inflammatory (NSAID), and its effect on gastrointestinal mucosa, complete blood counts (CBC) and biochemical indicators of liver and renal function were investigated in healthy cats using a randomized crossover design. A single dose of 4 mg\/kg of carprofen (Zenecarp\u00ae Injection), normal saline, or 20 mg\/kg of DL\u2010lysine acetyl salicylate (Vetalgine\u00ae) was given intravenously (i.v.) to each of five cats with a washout period of 2 weeks between treatments. Endoscopy of the stomach and duodenum 8 h postinjection revealed one acetyl salicylate\u2010(aspirin)\u2010treated cat with minor pinpoint erosions. None of the other cats in the three treatment groups had evidence of bleeding or ulceration. Serum biochemistry measurements of blood urea nitrogen (BUN), alanine transferase (ALT) and alkaline phosphatase (ALP) and complete blood counts (CBC) were not significantly altered from pretreatment values by the single dose of salicylate or carprofen (<jats:italic>P<\/jats:italic>&lt; 0.05). Early and extended sample time points suggest that the pharmacokinetics of carprofen in the cat fit a 2\u2010compartment model, with a long elimination half\u2010life (<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>) of 20.1 \u00b1\u200316.6 h, an area under the plasma concentration\u2013time curve (<jats:italic>AUC<\/jats:italic>) of 637 (\u00b1\u2003237) \u03bcg.mL\/h and a volume of distribution (<jats:italic>V<\/jats:italic>d<jats:sub>ss<\/jats:sub>) of 0.14 \u00b1\u20030.05 L\/kg. Intravenously administered aspirin fit a 2\u2010compartment model and had a long elimination half\u2010life (<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>) of 22.2 \u00b1\u20033.1 h, an<jats:italic>AUC<\/jats:italic>of 3824.2 \u00b1\u2003506.7 \u03bcg.mL\/h and a volume of distribution (<jats:italic>V<\/jats:italic>d<jats:sub>ss<\/jats:sub>) of 0.17 \u00b1\u20030.01 L\/kg.<\/jats:p>","DOI":"10.1046\/j.1365-2885.2000.00253.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T09:22:14Z","timestamp":1047460934000},"page":"73-79","source":"Crossref","is-referenced-by-count":47,"title":["The pharmacokinetics and effects of intravenously administered carprofen and salicylate on gastrointestinal mucosa and selected biochemical measurements in healthy cats"],"prefix":"10.1111","volume":"23","author":[{"family":"Parton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Balmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Whittem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Machon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1998.tb03623.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80356-3"},{"key":"e_1_2_6_4_2","first-page":"65","article-title":"Clinical Pharmacology of Salicylates.","volume":"176","author":"Davis 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