{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:33:00Z","timestamp":1785803580788,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"vor","delay-in-days":635,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2000,8,4]]},"abstract":"<jats:p>The influence of different pre\u2010 and post\u2010treatment fasting periods on the plasma availability and disposition kinetics of albendazole (ABZ) and its sulphoxide metabolite (ABZSO) in cattle was investigated. The effect of fasting on the distribution of ABZ and ABZSO to different target tissues\/fluids was also characterised. In Experiment I, 35 parasite\u2010free Holstein calves were divided into seven groups according to the following feeding conditions and treated intraruminally with ABZ (10 mg\/kg): control group (fed<jats:italic>ad libitum<\/jats:italic>), 24 h fasting either prior to (24 h pre\u2010) or post (24 h post\u2010) treatment, 24 h fasting with either 6 (6 h pre+18 h post) or 12 h (12 h pre+12 h post\u2010) of feed restriction prior to treatment, 12 h fasting either prior to (12 h pre\u2010) or post (12 h post) treatment. In Experiment II, calves from the same pool of animals were subjected to a 24 h fasting period prior to the same ABZ treatment and killed (two animals) at either 24, 36 or 48 h post\u2010administration to obtain samples of abomasal\/intestinal mucosa and fluid contents, bile and lungs. Plasma (Experiment I) and tissues\/fluids (Experiment II) samples were analysed by HPLC. All the fasting periods investigated induced marked changes to the plasma availability and disposition kinetics of the ABZSO metabolite. Enhanced plasma availability between 37 and 118%, delayed peak concentrations and extended mean residence times for ABZSO were observed in fasted compared to fed calves. The changes in plasma kinetics, reflecting an altered quantitative gastrointestinal absorption, were reflected in increased availability of ABZ and ABZSO in the target tissues\/fluids of fasted calves. The availabilities of ABZ and ABZSO in the gastrointestinal mucosa and fluids in fasted calves were markedly greater than in those fed<jats:italic>ad libitum<\/jats:italic>.<\/jats:p>","DOI":"10.1046\/j.1365-2885.2000.00265.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T09:22:20Z","timestamp":1047460940000},"page":"193-201","source":"Crossref","is-referenced-by-count":23,"title":["Enhanced plasma and target tissue availabilities of albendazole and albendazole sulphoxide in fasted calves: evaluation of different fasting intervals"],"prefix":"10.1111","volume":"23","author":[{"given":"S.","family":"S\u00c1NCHEZ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"ALVAREZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"SALLOVITZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"LANUSSE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(94)E0054-Q"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(94)E0055-R"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.1999.00194.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2460\/javma.1993.202.02.229","article-title":"Report of the AVMA Panel on Euthanasia","volume":"202","author":"American Veterinary Medical Association (AVMA)","year":"1993","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_6_1","volume-title":"Principles of drug disposition: the basis of veterinary clinical pharmacology","author":"Baggot J.","year":"1977"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826079208016326"},{"key":"e_1_2_6_8_1","volume-title":"Pharmaceutical Statistics: Practical and Clinical Applications","author":"Bolton S.","year":"1984"},{"key":"e_1_2_6_9_1","volume-title":"Guide to the care and use of experimental animals","author":"Canadian Council on Animal Care (CCAC)","year":"1980"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1201\/b14095"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1995.tb03472.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(94)90079-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1985.tb00956.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02214966"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(93)90232-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(97)00106-4"},{"key":"e_1_2_6_17_1","unstructured":"Hennessy D.(1999)Smart drenching\u2010pharmacokinetically based \u2018best use\u2019 of anthelmintic.Proceedings of the 17th International Conference of the World Association for the Advancement of Veterinary Parasitology Copenhagen. 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