{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:01:53Z","timestamp":1793325713486,"version":"4.5.0"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"vor","delay-in-days":173,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p> <jats:italic>Neisseria gonorrhoeae<\/jats:italic> (the gonococcus) is the causative agent of the sexually transmitted disease gonorrhoea. Most gonococcal infections remain localized to the genital tract but, in a small proportion of untreated cases, the bacterium becomes systemic to produce the serious complication of disseminated gonococcal infection (DGI). We have identified a large region of chromosomal DNA in <jats:italic>N. gonorrhoeae<\/jats:italic> that is not found in a subset of gonococcal isolates (a genetic island), in the closely related pathogen, <jats:italic>Neisseria meningitidis<\/jats:italic> or in commensal <jats:italic>Neisseria<\/jats:italic> that do not usually cause disease<jats:italic>.<\/jats:italic> Certain versions of the island carry a serum resistance locus and a gene for the production of a cytotoxin; these versions of the island are found preferentially in DGI isolates. All versions of the genetic island encode homologues of F factor conjugation proteins, suggesting that, like some other pathogenicity islands, this region encodes a conjugation\u2010like secretion system. Consistent with this hypothesis, a wild\u2010type strain released large amounts of DNA into the medium during exponential growth without cell lysis, whereas an isogenic strain mutated in a peptidoglycan hydrolase gene (<jats:italic>atlA<\/jats:italic>) was drastically reduced in its ability to donate DNA for transformation during growth. This genetic island constitutes the first major discriminating factor between the gonococcus and the other <jats:italic>Neisseria<\/jats:italic> and carries genes for providing DNA for genetic transformation.<\/jats:p>","DOI":"10.1046\/j.1365-2958.2001.02520.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T11:38:12Z","timestamp":1047469092000},"page":"263-277","source":"Crossref","is-referenced-by-count":182,"title":["A variable genetic island specific for <i>Neisseria gonorrhoeae<\/i> is involved in providing DNA for natural transformation and is found more often in disseminated infection isolates"],"prefix":"10.1111","volume":"41","author":[{"given":"Joseph P.","family":"Dillard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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