{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:10:59Z","timestamp":1794485459776,"version":"4.9.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,1,28]],"date-time":"2004-01-28T00:00:00Z","timestamp":1075248000000},"content-version":"vor","delay-in-days":180,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    DNA microarray covering the whole genome of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    strain N315 was prepared to investigate transcription profiles. The microarray analyses revealed that vancomycin induces transcription of 139 genes. Forty\u2010six genes among them failed to be induced in the\n                    <jats:italic>vraSR<\/jats:italic>\n                    null mutant KVR. Part of the genes regulated by VraSR system is associated with cell\u2010wall biosynthesis, such as PBP2, SgtB and MurZ. Other cell\u2010wall synthesis inhibitors also induced VraSR, suggesting that the sensor kinase VraS responds to the damage of cell\u2010wall structure or inhibition of cell\u2010wall biosynthesis. Additionally, the\n                    <jats:italic>vraSR<\/jats:italic>\n                    null mutants derived from hetero\u2010 and homo\u2010methicillin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    showed significant decrease of resistance against teicoplanin, \u03b2\u2010lactam, bacitracin and fosfomycin but not of\n                    <jats:sc>d<\/jats:sc>\n                    \u2010cycloserine and levofloxacin. The observation strongly indicates that VraSR constitutes a positive regulator of cell\u2010wall peptidoglycan synthesis, and that is deeply involved in the expression of \u03b2\u2010lactam and glycopeptide resistance in\n                    <jats:italic>S. aureus<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1046\/j.1365-2958.2003.03599.x","type":"journal-article","created":{"date-parts":[[2003,7,16]],"date-time":"2003-07-16T14:46:40Z","timestamp":1058366800000},"page":"807-821","source":"Crossref","is-referenced-by-count":465,"title":["Two\u2010component system VraSR positively modulates the regulation of cell\u2010wall biosynthesis pathway in\n                    <i>Staphylococcus 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