{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:51:49Z","timestamp":1761486709436},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"vor","delay-in-days":323,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>This study was performed to evaluate the role of tachykinin NK2 receptors in gastric barosensitivity and in postsurgical intestinal atony, using a selective NK2 antagonist (MEN 11420). Gastric distensions were performed in rats equipped with a gastric balloon and electrodes implanted in the neck muscles. Ileus was produced by laparotomy and caecum palpation in rats previously prepared with electrodes implanted on the proximal jejunum. Fifteen minutes before gastric distension or laparotomy, the animals received MEN 11420 (10, 100 or 200\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup> intravenously) or saline. The first distending pressure to increase the integrated neck electromyogram\u2003&gt; 100% was considered the pain threshold. MEN 11420 (100\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) increased significantly pain threshold (20.5\u2003\u00b1\u20031.2 vs. 17.0\u2003\u00b1\u20030.8\u2003mm Hg) but did not modify gastric volumes at the three doses tested. Abdominal surgery was followed by a total inhibition of jejunal spiking activity lasting 80.4\u2003\u00b1\u200318.7\u2003min. MEN 11420 (10 and 100\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) shortened the duration of motor inhibition by 36 and 39%, and induced a premature recovery of the phase III of migrating myoelectric complex at the lowest dose tested (130\u2003\u00b1\u200332 vs. 192\u2003\u00b1\u200328\u2003min). We conclude that NK2 receptors, probably located on afferent fibres, are involved in gastric barosensitivity and in postsurgical intestinal atony.<\/jats:p>","DOI":"10.1046\/j.1365-2982.2001.00239.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T15:16:40Z","timestamp":1047482200000},"page":"45-53","source":"Crossref","is-referenced-by-count":17,"title":["Role of NK2 receptors in gastric barosensitivity and in experimental ileus in rats"],"prefix":"10.1111","volume":"13","author":[{"given":"M.","family":"Toulouse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fioramonti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bu\u00e9no","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(94)00292-u"},{"key":"e_1_2_6_3_2","unstructured":"FurnessJB&CostaM.The Enteric Nervous SystemEdinburgh: Churchill Livingstone 1987."},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005164"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0163-7258(96)00195-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90589-2"},{"key":"e_1_2_6_7_2","first-page":"G824","article-title":"Effect of varying the rate and pattern of gastric distension on its sensory perception and motor activity","volume":"264","author":"Khan MI","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","unstructured":"CoffinB AzpirozF GuarnerF&MalageladaJR1994.Selective gastric hypersensitivity and reflex hyporeactivity in functionnal dyspepsia.Gastroenterology1994;107:1345\u201351.","DOI":"10.1016\/0016-5085(94)90536-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1998.00091.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(97)00169-3"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90065-5"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","unstructured":"ToulouseM CoelhoAM FioramontiJ LecciA MaggiC&Bu\u00e9noL.Role of tachykinin NK2 receptors in normal and altered rectal sensitivity in rats2000;129:193\u20139.","DOI":"10.1038\/sj.bjp.0703040"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01072353"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.8.955"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15869.x"},{"key":"e_1_2_6_16_2","first-page":"322","article-title":"Neurokinins induce a relaxation of the rat duodenum in vivo by activating postganglionic sympathetic elements in prevertebral ganglia: involvement of a NK\u20102 type of neurokinin receptor","volume":"246","author":"Giuliani S","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70214-9"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)94162-Q"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701587"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91007-5"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/S0016-5085(75)80138-7","article-title":"Electrical spiking activity and propulsion in small intestine in fed and fasted rats","volume":"68","author":"Ruckebusch M","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_6_22_2","first-page":"347","article-title":"A multifunction and programmable computerized barostat","volume":"17","author":"Hachet T","year":"1993","journal-title":"Gastroenterol Clin Biol"},{"key":"e_1_2_6_23_2","first-page":"A27111","article-title":"Visceral pain and referred hyperalgesia in rats with colon inflammation: role of tachykinins","volume":"25","author":"Olivar T","year":"1999","journal-title":"Soc Neurosci"},{"key":"e_1_2_6_24_2","first-page":"346","article-title":"Regulatory role of tachykinins on intestinal propulsive activity","volume":"31","author":"Onori L","year":"1999","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6405.1572"},{"key":"e_1_2_6_26_2","doi-asserted-by":"crossref","unstructured":"AndrewsPLR.Vagal afferent innervation of the gastrointestinal tract. 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