{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T16:44:24Z","timestamp":1726245864016},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,1,13]],"date-time":"2002-01-13T00:00:00Z","timestamp":1010880000000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2001,12,9]]},"abstract":"<jats:p>Lipopolysaccharide (LPS)\u2010induced intestinal endotoxaemia perturbs motility and causes activation and influx of inflammatory cells into the muscle tissue. Because rat submandibular gland peptide T (SGP\u2010T; Thr\u2010Asp\u2010Ile\u2010Phe\u2010Glu\u2010Gly\u2010Gly), its carboxyl\u2010terminal fragment tripeptide, FEG (Phe\u2010Glu\u2010Gly) and its <jats:sc>D<\/jats:sc>\u2010isomeric analogue, feG, modulate intestinal anaphylactic reactions, we examined whether these peptides also modulate LPS\u2010induced intestinal endotoxaemia in conscious rats. The disruption of the fasting pattern of intestinal MMCs (migrating motor complexes), induced by intravenous LPS (20\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) injection, was prevented by all three peptides. The extravasation of leucocytes into the peritoneal cavity and increased expression of the activation marker CD18 on mesenteric tissue leucocytes (18\u2003h after intraperitoneal injection of LPS) were reduced by orally administered feG, which also significantly decreased the number of intestinal tissue leucocytes expressing the integrin CD18. We conclude that feG attenuates both the immediate (intestinal motility) and late (\u223c\u200318\u2003h) inflammatory reactions provoked by endotoxaemia.<\/jats:p>","DOI":"10.1046\/j.1365-2982.2001.00294.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T15:17:13Z","timestamp":1047482233000},"page":"599-603","source":"Crossref","is-referenced-by-count":8,"title":["The tripeptide feG reduces endotoxin\u2010provoked perturbation of intestinal motility and inflammation"],"prefix":"10.1111","volume":"13","author":[{"given":"R.","family":"Mathison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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