{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:48:57Z","timestamp":1763765337124},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":664,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>In order to study the role of the costimulatory signals in Th2 cytokine production, monoclonal antibodies (mAbs) against cell adhesion molecules (CAMs) were added to cultured cells obtained from the mesenteric lymph nodes (MLNs) of mice infected with Trichinella spiralis<jats:italic>, followed by a determination of interleukin (IL)\u20105 and IL\u20104 in the culture supernatant. IL\u20105 production by MLN cells stimulated with somatic antigen was significantly reduced by addition of anti\u2010CD86 but not by anti\u2010CD80 mAb. Combination of anti\u2010CD80 and anti\u2010CD86 mAbs reduced IL\u20105 production most effectively. IL\u20104 production induced by anti\u2010CD3 mAb was suppressed only by the addition of anti\u2010CD86 mAb. Blockade of the ICAM\u20101\/LFA\u20101 and VCAM\u20101\/VLA\u20134 interactions was less effective on the production of IL\u20105 and IL\u20104 than the addition of anti\u2010CD86 mAb alone. In contrast to the <\/jats:italic>in vitro<jats:italic> cytokine production, intraperitoneal injection of anti\u2010CD80, anti\u2010CD86 mAb, or both, similarly suppressed the peak of the eosinophilia on day 21. Elevation of somatic antigen\u2010specific IgE and IgG1 levels as well as total IgE was not inhibited by the administration of anti\u2010CD80, anti\u2010CD86 mAb or both. In\u2010vitro and in\u2010vivo effects of CTLA\u20104 immunoglobulin were similar to those of combined treatment with anti\u2010CD80 and anti\u2010CD86 mAbs. These results suggest that the interaction between antigen\u2010presenting cells and CD4 T cells through CD86 are most important in Th2 response during <\/jats:italic>T. spiralis <jats:italic>infection<\/jats:italic>.<\/jats:p>","DOI":"10.1046\/j.1365-3024.2000.00282.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:09:10Z","timestamp":1047488950000},"page":"121-130","source":"Crossref","is-referenced-by-count":10,"title":["Costimulatory signal through CD86 is important in Th2 response in <i>Trichinella spiralis<\/i> infected mice"],"prefix":"10.1111","volume":"22","author":[{"family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Takamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Sugane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-3024.2000.00282.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-3024.2000.00282.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T12:58:17Z","timestamp":1698584297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-3024.2000.00282.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["10.1046\/j.1365-3024.2000.00282.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-3024.2000.00282.x","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}