{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T05:25:34Z","timestamp":1697520334973},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"vor","delay-in-days":295,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p>Antisheath antibodies have been incriminated in elimination of circulating microfilariae in human filariasis since a very significant inverse association has been consistently demonstrated between the two parameters. An attempt was made in the present study to seek empirical proof for the above proposal. Two cohorts of 43 and 73 microfilariae (mf) carriers were examined after 13 and 10\u2003years, respectively, for mf as well as antisheath antibodies. The first cohort was also examined for the presence of circulating filarial antigen (CFA). Of the 43 mf carriers examined after 13\u2003years, 62\u00b78% were free of circulating mf although only 3\u00b77% of them had demonstrable antisheath antibodies. Approximately 93% of this cohort (with or without current microfilaraemia) tested positive for CFA after 13\u2003years indicating continued presence of adult filarial worms in the host after loss of mf in circulation. When the second cohort of 73 mf carriers were examined after 10\u2003years, 30 were found to be amicrofilaraemic and only 6\u00b766% of them had demonstrable antisheath antibodies. We conclude that, in human Bancroftian filariasis, elimination of circulating microfilariae may not be mediated by antibodies to microfilarial sheath.<\/jats:p>","DOI":"10.1046\/j.1365-3024.2001.00367.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:10:26Z","timestamp":1047489026000},"page":"163-167","source":"Crossref","is-referenced-by-count":8,"title":["Human Bancroftian filariasis: loss of patent microfilaraemia is not associated with production of antibodies to microfilarial sheath"],"prefix":"10.1111","volume":"23","author":[{"given":"A.K.","family":"Satapathy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.K.","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"Babu Geddam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Ravindran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000057127"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.4269\/ajtmh.1988.39.373","article-title":"Induction of protective immunity in dogs to infection with Dirofilaria immitis using chemically abbreviated infections","volume":"39","author":"Grieve RB","year":"1988","journal-title":"Am J Trop Med Hygiene"},{"key":"e_1_2_5_4_2","first-page":"508","article-title":"Brugia malayi: relationship between anti\u2010sheath antibodies and amicrofilaraemia in natives living in an endemic area of south Kalimantan, Borneo","volume":"29","author":"McGreevy PB","year":"1981","journal-title":"Am J Trop Med Hygiene"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1990.11812516"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00022677"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470513446.ch15"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4269\/ajtmh.1987.37.143","article-title":"Dynamics of immune responses related to clinical status in Brugia pahangi infected dogs","volume":"37","author":"Snowden KF","year":"1987","journal-title":"Am J Trop Med Hygiene"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.8.2.228-232.1978"},{"key":"e_1_2_5_10_2","first-page":"151","article-title":"Studies on Dipetalonema viteae (Filarioidea). 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