{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:35:45Z","timestamp":1761154545914},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,11,3]],"date-time":"2003-11-03T00:00:00Z","timestamp":1067817600000},"content-version":"vor","delay-in-days":2711,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[1996,6]]},"abstract":"<jats:p>The authors describe the immunological profile of BALB\/c mice with Mite\u2010Associated Ulcerative Dermatitis (MAUD)\u2010like disease, due to <jats:italic>Myocoptes musculinus<\/jats:italic> (Koch 1844) infestation. The disease probably involves allergic mechanisms and is characterized by erythematous and pruritic skin lesions, widespread hair loss, lymphadenopathy, lymphocytopenia, granulocytosis and wasting. Affected individuals had much reduced numbers of pre\u2010B and B cells in bone marrow and B cells in blood; decreased T\u2010cell numbers in peripheral lymphoid organs and blood; hypergammaglobulinaemia with selective increases of IgG1, IgE and IgA, and depletion on IgM and IgG3, the same isotype distribution being detected in splenic plasmocytes; qualitative modifications of the serum antibody reactivity pattern; and increased production of IL\u20104 with decreased IL\u20102 production after <jats:italic>in vitro<\/jats:italic> polyclonal stimulation of T cells. Taken together, these results suggest that infestation by <jats:italic>M. musculinus<\/jats:italic> in BALB\/c mice leads to a significant immunological disorder resulting in a T\u2010helper\u20102 (Th\u20102) type response, with marked systemic consequences. This pathological condition may thus provide a useful model system for the immunobiological perturbation associated with chronic allergic disease.<\/jats:p>","DOI":"10.1046\/j.1365-3083.1996.d01-259.x","type":"journal-article","created":{"date-parts":[[2003,11,3]],"date-time":"2003-11-03T20:37:25Z","timestamp":1067891845000},"page":"604-612","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Murine Acariasis. II. Immunological Dysfunction and Evidence for Chronic Activation of Th\u20102 Lymphocytes"],"prefix":"10.1111","volume":"43","author":[{"given":"P.","family":"JUNGMANN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"FREITAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"BANDEIRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"NOBREGA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"COUTINHO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010A.","family":"MARCOS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"MINOPRIO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,11,3]]},"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-3083.1996.d01-259.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-3083.1996.d01-259.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-3083.1996.d01-259.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:13:59Z","timestamp":1694391239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-3083.1996.d01-259.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,6]]}},"alternative-id":["10.1046\/j.1365-3083.1996.d01-259.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-3083.1996.d01-259.x","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,6]]},"assertion":[{"value":"2003-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}