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Because the IgG1 antibody response is extraordinarily strong, the role of interleukin (IL)\u20104, important for IgG1 synthesis, was investigated. Both C57BL\/6 and NZB IL\u20104\u2010deficient mice produced IgG1\u2010RF antibodies after injection with RF\u2010like immune complexes, although the antibody levels were slightly delayed compared to wild type mice. This shows that IL\u20104 is not obligatory in RF\u2010like immune complex induced IgG1\u2010RF production. A discrepancy in the decline of serum IgG1\u2013RF was noted between NZB and C57Bl\/6 mice. Serum IgG1\u2013RF declined 43\u2003days postinjection (p.i.), in C57BL\/6 mice whereas high serum levels of IgG1\u2013RF were maintained more than 100\u2003days in the NZB mice, indicating different regulatory mechanisms in these mice. To study if the affinity for mouse IgG increased with time in NZB mice and thus become more directed against self, the cross\u2010reactivity of the IgG1\u2013RF antibodies with IgG from other species was investigated early and late after injection. It was, however, found that the cross\u2010reactivity with IgG of human, goat and rabbit origin did not change between the two time points.<\/jats:p>","DOI":"10.1046\/j.1365-3083.2001.00828.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T20:15:28Z","timestamp":1047500128000},"page":"32-39","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immune Complex\u2010Induced Chronic and Intense IL\u20104 Independent IgG1\u2010Rheumatoid Factor Production in NZB 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