{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T21:19:23Z","timestamp":1721164763022},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2744,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p> <jats:italic>Schistosoma mansoni<\/jats:italic> infection proceeds in normal mice in the absence of detectable levels of polyclonal or specific immunoglobulin (Ig)E until worms mature and deposit eggs. Hence, the course of a primary <jats:italic>S. mansoni<\/jats:italic> infection is not expected to vary appreciably in mice with defects in the IgE production. Experimental increase of IgE production early after infection may, however, influence worm development. In the first approach towards this goal, BALB\/<jats:italic>c<\/jats:italic> mice were injected with interleukin(IL)4 to raise the level of endogenously synthesized IgE. A significant increase in serum polyclonal IgE and antischistosome IgG1 during the prepatent period was not associated with significant changes in worm and egg burden or liver pathology. During the second approach, mice were injected with IgE which was affinity purified from serum of BALB\/<jats:italic>c<\/jats:italic> mice infected for 16 weeks with <jats:italic>S. mansoni.<\/jats:italic> The purified IgE bound to carbohydrate\u2010independent epitopes of soluble antigens from 3\u2003h larvae, adult worms and eggs and recognized the schistosomular surface membrane. No differences in worm and egg load or granuloma number and size were noted between untreated and exogenous IgE\u2010injected mice. Together, the data demonstrate that by itself IgE does not influence the outcome of infection in primary murine <jats:italic>S. mansoni.<\/jats:italic><\/jats:p>","DOI":"10.1046\/j.1365-3083.2001.00835.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T20:15:28Z","timestamp":1047500128000},"page":"24-31","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of IgE in Primary Murine <i>Schistosomiasis mansoni<\/i>"],"prefix":"10.1111","volume":"53","author":[{"given":"R.","family":"El Ridi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Afifi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8009216"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830160602"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1997.d01-184.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1993.tb00565.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1993.tb00566.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220622"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4269\/ajtmh.1997.57.487","article-title":"Factors affecting high and low human IgE responses to schistosome worm antigens in an area of Brazil endemic for Schistosoma mansoni and hookworm","volume":"57","author":"Webster M","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1128\/IAI.67.2.636-642.1999","article-title":"Role of adult worm antigen\u2010specific immunoglobulin E in acquired immunity to Schistosoma mansoni infection in baboons","volume":"67","author":"Nyindo M","year":"1999","journal-title":"Infect Immun"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4049\/jimmunol.131.3.1460","article-title":"Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae IV. 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