{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T16:47:40Z","timestamp":1761842860631},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,23]],"date-time":"2001-12-23T00:00:00Z","timestamp":1009065600000},"content-version":"vor","delay-in-days":297,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p>Midtrimester amniotic fluid cytokines may reflect the function of the maternal immune system in the maternal\u2013fetal interface and thus be predictive of pre\u2010eclampsia. We determined the concentrations of interleukin (IL)\u20106, IL\u20108, IL\u201010, IL\u201011, IL\u201012, IL\u201015, tumour necrosis factor (TNF)\u2010\u03b1 and transforming growth factor (TGF)\u2010\u03b2 in amniotic fluid at 14\u201316\u2003weeks of gestation from women with normal pregnancies and from those who subsequently developed severe pre\u2010eclampsia. The concentrations of the cytokines in amniotic fluid did not significantly differ between patients and normal controls. The median concentration of IL\u20106 was 950\u2003pg\/ml in normal pregnant women and 578\u2003pg\/ml in the patient group. The median concentration of IL\u20108 was 606\u2003pg\/ml in normal controls and 294\u2003pg\/ml in the patient group. The levels of IL\u20106, IL\u20108 and TGF\u2010\u03b2 correlated positively with each other. TNF\u2010\u03b1 concentrations were low and similar in both groups. IL\u201010 and IL\u201012 were detected at very low levels in 37 and 7% of the samples, respectively. No difference was found in IL\u201015 concentrations between the groups. IL\u201011 was found only at low levels in both groups. Although none of the cytokines measured was predictive of pre\u2010eclampsia, this study provides information of cytokines in amniotic fluid during the period when the spiral arteries are remodelled.<\/jats:p>","DOI":"10.1046\/j.1365-3083.2001.00872.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T20:16:00Z","timestamp":1047500160000},"page":"310-314","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Cytokine Levels in Midtrimester Amniotic Fluid in Normal Pregnancy and in the Prediction of 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