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We detected concentrations of IL\u20104 in pg\/ml when larval excretory\u2013secretory products and crude extract from <jats:italic>A. simplex<\/jats:italic> were investigated by ELISA. Specific antibodies were obtained by immunization of rabbits with mouse IL\u20104 and tested in ELISA against <jats:italic>A. simplex<\/jats:italic> antigens obtaining higher values of optical density, that were confirmed by western blot analysis. The absorption of these sera with <jats:italic>A. simplex<\/jats:italic> antigen resulted in a 70\u201380% inhibition of antigen binding when retested in ELISA. We demonstrated that <jats:italic>A. simplex<\/jats:italic> antigens react with antibodies raised against vertebrate IL\u20104. The results obtained by us support the hypothesis that <jats:italic>A. simplex<\/jats:italic> shares several epitopes with IL\u20104, important for the Th2 response development in human anisakiasis, where the parasite may modulate the Th1\u2013Th2 dichotomy for its own benefit by mucosal inflammation control in an attempt to avoid the larval expelling.<\/jats:p>","DOI":"10.1046\/j.1365-3083.2001.00905.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T20:16:27Z","timestamp":1047500187000},"page":"483-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Presence of IL\u20104\u2010Like Molecules in Larval Excretory\u2010Secretory Products and Crude Extracts from <i>Anisakis simplex<\/i>"],"prefix":"10.1111","volume":"53","author":[{"given":"C.","family":"Cu\u00e9llar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jes\u00fas Perteguer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rodero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2732-8_3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.2.3.278"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050174"},{"key":"e_1_2_6_5_2","first-page":"1","article-title":"Studies on the immunological diagnosis of anisakiasis. 3. 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