{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:54:37Z","timestamp":1791312877167,"version":"4.3.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,1,24]],"date-time":"2002-01-24T00:00:00Z","timestamp":1011830400000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p>\n                    Human T lymphotropic virus type I (HTLV\u2010I) induces HTLV\u2010I\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) and adult T\u2010cell leukemia (ATL). The development of HAM\/TSP is associated with rapid maturation of dendritic cells (DCs), while ATL is accomplished with their maturation defect. The DC maturation is induced by cell\u2010to\u2010cell contact with CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells expressing CD40 ligand (L). We determined the influence of CD40L expressed on various HTLV\u2010I\u2010infected T cells on the DC maturation. Around 60% of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells infected with HTLV\u2010I for 1 week, expressed CD40L molecules involved in DC maturation. DCs matured by the CD40L\n                    <jats:sup>+<\/jats:sup>\n                    T cells activated autologous CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. HTLV\u2010I\u2010immortalized T\u2010cell lines established from healthy donors consistently expressed CD40L molecules for 3\u2003months, however, some lines lost the expression soon thereafter. Interleukin (IL)\u20102\u2010independent and transformed lines lacked that expression. Furthermore, T cells obtained from HAM\/TSP patients expressed CD40L molecules for at least 3\u2003weeks, whereas T cells from ATL patients did not express that. The CD40L\n                    <jats:sup>\u2212<\/jats:sup>\n                    T cells did not induce DC maturation, and required exogenous CD40L molecules for maturation. The CD40L\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell\u2010induced maturation was blocked by anti\u2010CD40L antibody. Therefore, the lack of CD40L expression on HTLV\u2010I\u2010infected T cells may be associated with the development of ATL.\n                  <\/jats:p>","DOI":"10.1046\/j.1365-3083.2001.01003.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T15:17:28Z","timestamp":1047482248000},"page":"574-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of CD40 Ligand Expression on HTLV\u2010I\u2010Infected T Cells and Maturation of Dendritic Cells"],"prefix":"10.1111","volume":"54","author":[{"given":"M.","family":"Makino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Utsunomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shimokubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Izumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1,24]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"73","volume-title":"Hematology","author":"Takatsuki K","year":"1977"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T\u2010cell leukemia. 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