{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:10:36Z","timestamp":1770498636072,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":693,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p><jats:bold>Summary<\/jats:bold> We compared the efficacy and tolerability of oral piroxicam 1\u00a0mg\/kg\/day with soluble aspirin given at 100\u00a0mg\/kg\/day taken four\u2010hourly in 58 patients with sickle cell anaemia and severe ostcoarticular painful attacks requiring hospitalization in a randomized, paralleled study. Main investigational criteria were pain relief, limitation of movement, fever, and insomnia or agitation. Both groups were well\u2010matched at the commencement of therapy but most patients on piroxicam showed remarkable and significant pain relief and improvement in other parameters within 24\u00a0h. Unwanted effects were absent in the piroxicam\u2010treated group whereas those treated with aspirin experienced nausea and vomiting. There were no significant changes in liver function tests with both forms of treatment. Oral piroxicam is an effective and safe treatment in the management of the osteoarticular painful crisis in sickle cell anaemia. It might prevent the use of parenteral analgesics and hospitalization and reduce the loss of school hours in patients who are being treated for bone pain crises that characterize sickle cell anaemia.<\/jats:p>","DOI":"10.1046\/j.1365-3156.2000.00507.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T21:34:19Z","timestamp":1047504859000},"page":"81-84","source":"Crossref","is-referenced-by-count":24,"title":["An open comparative study of dispersible piroxicam versus soluble acetylsalicylic acid for the treatment of osteoarticular painful attack during sickle cell crisis"],"prefix":"10.1111","volume":"5","author":[{"given":"Felicia U.","family":"Eke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Obamyonyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Ndubuisi","family":"Eke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A.","family":"Oyewo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.63.742.605"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606193142501"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.69.2.256"},{"key":"e_1_2_6_5_1","first-page":"742","article-title":"Sickle cell anaemia in children in Eastern Nigeria. A detailed analysis of 210 cases.","volume":"59","author":"Kaine WN","year":"1982","journal-title":"East African Medical Journal"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36723-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1542\/peds.79.2.309","article-title":"Pain, a subject ignored.","volume":"79","author":"Rana SR","year":"1987","journal-title":"Paediatrics"},{"key":"e_1_2_6_8_1","first-page":"597","article-title":"Intramuscular piroxicam treatment of painful articular attacks in sickle cell disease.","volume":"47","author":"Sangare A","year":"1990","journal-title":"Current Therapy Research"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb08317.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07330-3"},{"key":"e_1_2_6_11_1","first-page":"39","article-title":"Parenteral piroxicam in the management of fever arthralgia and musculoskeletal conditions of acute malaria.","volume":"25","author":"Walker O","year":"1993","journal-title":"Nigerian Medical Practice"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-3156.2000.00507.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-3156.2000.00507.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T15:51:50Z","timestamp":1698594710000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-3156.2000.00507.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["10.1046\/j.1365-3156.2000.00507.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-3156.2000.00507.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}