{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:04:19Z","timestamp":1763366659714},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":693,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p><jats:bold>Summary<\/jats:bold> We conducted a seroepidemiological survey of human plague in the general population using random sampling in the area of Ambositra, the main focus of plague in the central highlands of Madagascar (520 confirmed and presumptive cases notified during the past 10\u00a0years). Sera were tested using an ELISA IgG F1 assay. Considering the internal validity of the assay and the sampling method, the overall corrected prevalence of F1 antibodies was 0.6% (95% CI: 0.2%\u20101.8%). Being nearly 0\u00a0up to the age of 40, the corrected prevalence increased markedly after 45\u00a0years to 6.2%. Six of 20 individuals who declared to have been treated for clinical suspicion of bubonic plague in the past had F1 antibodies. The seroprevalence did not differ according to gender except in individuals &gt;\u00a060, where antibodies were significantly more frequent in males. This study suggests that the number of clinically suspected cases of plague provided by the surveillance network was plausible, despite some true cases being missed and a significant number of false positives. We also confirm that <jats:italic>Yersinia pestis<\/jats:italic> infections may occur without marked clinical manifestations and patients may recover without treatment, in accordance with old observations of pestis minor.<\/jats:p>","DOI":"10.1046\/j.1365-3156.2000.00521.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T21:34:19Z","timestamp":1047504859000},"page":"94-98","source":"Crossref","is-referenced-by-count":9,"title":["Seroepidemiology of human plague in the Madagascar highlands"],"prefix":"10.1111","volume":"5","author":[{"given":"M.","family":"Ratsitorahina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rabarijaona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Chanteau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Boisier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"9","article-title":"Epid\u00e9miologie de la peste \u00e0 Madagascar.","volume":"35","author":"Brygoo ER","year":"1966","journal-title":"Archives de l'Institut Pasteur de Madagascar"},{"key":"e_1_2_6_3_1","first-page":"53","article-title":"La peste \u00e0 Madagascar: donn\u00e9es \u00e9pid\u00e9miologiques de 1989 \u00e0 1995 et programme national de lutte.","volume":"7","author":"Ribes G","year":"1997","journal-title":"Sant\u00e9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0401.980114"},{"key":"e_1_2_6_5_1","first-page":"446","article-title":"Observations sur un cas de Pestis minor.","volume":"24","author":"Fonquernie J","year":"1931","journal-title":"Bulletin de la Soci\u00e9t\u00e9 de Pathologie Exotique"},{"key":"e_1_2_6_6_1","first-page":"332","article-title":"Etude s\u00e9ro\u2010\u00e9pid\u00e9miologique de la peste humaine \u00e0 Madagascar.","volume":"55","author":"Leroy F","year":"1997","journal-title":"Annales de Biologie Clinique"},{"key":"e_1_2_6_7_1","first-page":"165","article-title":"Absence de Yersinia pathog\u00e8nes autres que Y. pestis\u00e0 Madagascar.","volume":"62","author":"Leroy F","year":"1995","journal-title":"Archives de l'Institut Pasteur de Madagascar"},{"key":"e_1_2_6_8_1","volume-title":"La Peste","author":"Pollitzer R","year":"1954"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1128\/cdli.4.5.587-591.1997","article-title":"Field evaluation of an immunoglobulin G anti\u2010F1 enzyme\u2010linked immunosorbent assay for serodiagnosis of human plague in Madagascar.","volume":"4","author":"Rasoamanana B","year":"1997","journal-title":"Clinical and Diagnostic Laboratory Immunology"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112510"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-3156.2000.00521.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-3156.2000.00521.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T15:52:04Z","timestamp":1698594724000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-3156.2000.00521.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["10.1046\/j.1365-3156.2000.00521.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-3156.2000.00521.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}