{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:39:17Z","timestamp":1789767557552,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":693,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p><jats:bold>Summary<\/jats:bold> In a <jats:italic>Schistosoma haematobium<\/jats:italic>\u2010endemic village in western Madagascar we evaluated ultrasonography and Eosinophil Cationic Protein (ECP) in urine as means to detect the associated urinary tract pathology. 192 individuals were matched according to age and sex, and grouped into infected persons with bladder and, if present, kidney pathology (<jats:italic>n<\/jats:italic>=\u00a096); infected persons without pathology (<jats:italic>n<\/jats:italic>=\u00a048) and noninfected persons without pathology (<jats:italic>n<\/jats:italic>=\u00a048). The median urinary egg count was significantly higher in individuals with ultrasonographically detectable urinary tract pathology (115 eggs\/10\u00a0ml urine) than in infected persons without (45 eggs\/10\u00a0ml of urine). At 136\u00a0ng\/ml, the median ECP level was significantly higher in the 144 infected individuals than in the 48 noninfected persons (0.35\u00a0ng\/ml). Egg excretion correlated positively with ECP level. The median ECP level was significantly higher in the group with ultrasonographically detectable urinary tract pathology than in the group without (183\u00a0ng\/ml <jats:italic>vs<\/jats:italic>. 67\u00a0ng\/ml). The results suggest that minor degrees of pathology, particularly at an early stage of infection with <jats:italic>S. haematobium<\/jats:italic>, might be overlooked by ultrasonography despite the presence of marked inflammation, as indicated by markedly increased urinary ECP levels in infected individuals without ultrasonographically detectable urinary tract pathology. ECP may therefore provide important information on the evolution of <jats:italic>S. haematobium<\/jats:italic>\u2010associated urinary tract morbidity.<\/jats:p>","DOI":"10.1046\/j.1365-3156.2000.00522.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T21:34:19Z","timestamp":1047504859000},"page":"88-93","source":"Crossref","is-referenced-by-count":24,"title":["Morbidity assessment in urinary schistosomiasis infection through ultrasonography and measurement of eosinophil cationic protein (ECP) in urine"],"prefix":"10.1111","volume":"5","author":[{"given":"Peter D. C.","family":"Leutscher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus M.","family":"Reimert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte J.","family":"Vennervald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Voahangy E.","family":"Ravaoalimalala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Ramarokoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Serieye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ando","family":"Raobelison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamy","family":"Rasendramino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels O.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Esterre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"139","article-title":"Comparison of ultrasonography, intravenous pyelography and cystoscopy in detection of urinary lesions due to Schistosoma haematobium.","volume":"43","author":"Burki A","year":"1986","journal-title":"Acta Tropica"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/256727a0"},{"key":"e_1_2_6_4_1","first-page":"45","article-title":"The use of diagnostic ultrasound in schistosomiasis \u2013 attempts at standardization of methodology.","volume":"52","author":"Cairo Working Group","year":"1992","journal-title":"Acta Tropica"},{"key":"e_1_2_6_5_1","first-page":"273","article-title":"Les Bilharzioses humaines \u00e0 Madagascar. R\u00e9partition g\u00e9ographique et pr\u00e9valence.","volume":"46","author":"Coulanges P","year":"1978","journal-title":"Archives de L'Institut Pasteur de Madagascar"},{"key":"e_1_2_6_6_1","first-page":"145","article-title":"Morbidity in urinary schistosomiasis: relation between sonographical lesions and pathological urine findings.","volume":"36","author":"Doehring E","year":"1985","journal-title":"Tropical Medicine Parasitology"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/92.3.329"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(92)90016-Q"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.4269\/ajtmh.1998.59.775","article-title":"Evolution of Schistosoma haematobium\u2010related pathology over 24 months after treatment with praziquantel among schoolchildren in Southeastern Tanzania.","volume":"59","author":"Hatz CF","year":"1998","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(73)90079-5"},{"key":"e_1_2_6_11_1","first-page":"493","article-title":"Arginine\u2010rich cationic proteins of human eosinophil granules. Comparison of the constituents of the eosinophilic and neutrophilic leukocytes.","volume":"36","author":"Olsson I","year":"1977","journal-title":"Laboratory Invest"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/3279081"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(91)90177-H"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(93)90063-H"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(96)90521-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80456-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(93)90458-3"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(96)00038-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(98)01311-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(96)10019-3"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-3156.2000.00522.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-3156.2000.00522.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T15:52:10Z","timestamp":1698594730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-3156.2000.00522.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["10.1046\/j.1365-3156.2000.00522.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-3156.2000.00522.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}