{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:09:21Z","timestamp":1750478961881},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":664,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p><jats:bold>Summary<\/jats:bold>  <jats:sc>OBJECTIVES<\/jats:sc>\u2002\u2002To assess the cost\u2010effectiveness of three alternative screening strategies in delivering treatment to patients presenting with symptoms suggestive of <jats:italic>S. mansoni<\/jats:italic>, using data collected from 17 PHCCs in the Rusizi Plain, Burundi. The three strategies were: (1) screening all symptomatic patients using a Kato\u2010Katz smear and treating only the ones found positive; (2) treating all symptomatic patients or (3) treating only those presenting with symptoms of severe diarrhoea (blood in stool).<\/jats:p><jats:p> <jats:sc>METHODS<\/jats:sc>\u2002\u2002The database consisted of 41\u00a0051 visits of symptomatic patients to the 17 PHCCs during 1990. Effectiveness was measured as the number of infected patients treated (gold standard: 25\u2010mg Kato\u2010Katz smear). Cost\u2010effectiveness ratios (CERs) (cost in US$ per infected patient treated) were used to compare the control strategies. Sensitivity analysis was performed to assess the effect of drug price and prevalence of infection on the CERs.<\/jats:p><jats:p> <jats:sc>RESULTS<\/jats:sc>\u2002\u2002The overall prevalence of <jats:italic>S. mansoni<\/jats:italic> infection was 9.5% (95% CI\u00a0=\u00a09.1%, 9.9%). Treating only those with severe symptoms of infection would have left 92% of infected patients untreated. Performing a Kato\u2010Katz smear to confirm the diagnosis was more cost\u2010effective than treating all symptomatic patients on a presumptive basis, with CERs of 4.2 US$ and 12.43 US$ per infected person treated, respectively. Sensitivity analysis showed that, for a cost of 0.99 US$ per dose of praziquantel, the Kato\u2010Katz option remained the most cost\u2010effective approach for prevalences under 76%. For a drug price of 0.21 US$ per dose, both strategies would have become equivalent. The latter value varied extensively per PHCC (range 0.17 US$ to 0.51 US$), due to the different prevalences of infection (range 0.5% to 34.3%).<\/jats:p><jats:p> <jats:sc>CONCLUSION<\/jats:sc>\u2002\u2002We found that using severe diarrhoea as an indicator for infection was not appropriate, and that screening symptomatic patients with the Kato\u2010Katz method remained the most cost\u2010effective approach in the given setting. The CER of treating all symptomatic patients on a presumptive basis depended very much on the drug price and the endemic level.<\/jats:p>","DOI":"10.1046\/j.1365-3156.2000.00530.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T21:34:41Z","timestamp":1047504881000},"page":"192-202","source":"Crossref","is-referenced-by-count":22,"title":["A comparative analysis of the cost\u2010effectiveness of treatment based on parasitological and symptomatic screening for <i>Schistosoma mansoni<\/i> in Burundi"],"prefix":"10.1111","volume":"5","author":[{"given":"H\u00e9l\u00e8ne","family":"Carabin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Guyatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Engels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1997.d01-209.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(90)90037-F"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(92)90173-A"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-199512000-00012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(98)01323-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4269\/ajtmh.1977.26.109","article-title":"Morbidity from Schistosoma mansoni in a Puerto Rican community: a population\u2010based study.","volume":"26","author":"Cline BL","year":"1977","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_6_8_1","first-page":"769","article-title":"Antihelmintics. 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