{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:44:40Z","timestamp":1788601480952,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":572,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p><jats:bold>Summary<\/jats:bold> The aim of studies on plant molluscicides is to complement methods for controlling snails acting as intermediate hosts of schistosomes. We report on the toxic activity of extracts from <jats:italic>Jatropha curcas<\/jats:italic> L. (Euphorbiaceae) against snails transmitting <jats:italic>Schistosoma mansoni<\/jats:italic> and <jats:italic>S. haematobium<\/jats:italic>. We studied different extracts' effects on infectious larvae, cercariae and miracidia of <jats:italic>S. mansoni<\/jats:italic>. Compared to aqueous extract, methanol extract showed the highest toxicity against all tested organisms with LC<jats:sub>100<\/jats:sub>\u2010values of 25\u00a0p.p.m. for cercariae and the snail <jats:italic>Biomphalaria glabrata<\/jats:italic> and 1\u00a0p.p.m. for the snails <jats:italic>Bulinus truncatus<\/jats:italic> and <jats:italic>B. natalensis<\/jats:italic>. Attenuation of cercariae leading to reduced infectivity in mice could be achieved in concentrations below those exerting acute toxicity. In view of our results and the ongoing exploitation of <jats:italic>J. curcas<\/jats:italic> for other purposes, this plant could become an affordable and effective component of an integrated approach to schistosomiasis control.<\/jats:p>","DOI":"10.1046\/j.1365-3156.2000.00573.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T21:34:57Z","timestamp":1047504897000},"page":"423-430","source":"Crossref","is-referenced-by-count":76,"title":["Toxic activities of the plant Jatropha curcas against intermediate snail hosts and larvae of schistosomes"],"prefix":"10.1111","volume":"5","author":[{"given":"Melanie","family":"Rug","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Ruppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(74)90043-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(75)90057-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(84)83091-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098587901600411"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(82)90064-X"},{"key":"e_1_2_6_7_1","first-page":"82","article-title":"Effects of phorbol esters in carp (Cyprinus carpio L.).","volume":"40","author":"Becker 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die lokale Seifenherstellung im Sahel.","volume":"53","author":"Henning R","year":"1995","journal-title":"Der Tropenlandwirt"},{"key":"e_1_2_6_15_1","first-page":"5800","article-title":"A new tumor promoter from the seed oil of Jatropha curcas L., an intramolecular diester of 12\u2010deoxy\u201016\u2010hydroxyphorbol.","volume":"48","author":"Hirota M","year":"1988","journal-title":"Cancer Research"},{"key":"e_1_2_6_16_1","first-page":"223","article-title":"Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand.","volume":"78","author":"Horiuchi T","year":"1987","journal-title":"Japanese Journal of Cancer Research"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-971396"},{"key":"e_1_2_6_18_1","first-page":"729","article-title":"Acute poisoning with Jatropha curcas purging nut tree in children.","volume":"65","author":"Joubert PH","year":"1984","journal-title":"South African Medical 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