{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:51:48Z","timestamp":1761486708512},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":2805,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p><jats:bold>Summary<\/jats:bold> In a double blind design the tolerability and efficacy of single\u2010dose DEC (6\u00a0mg\/kg\/body weight) or ivermectin (400\u00a0\u03bcg\/kg\/body weight) was studied in 30 asymptomatic <jats:italic>W. bancrofti<\/jats:italic> parasite carriers each. Although both drugs were tolerated well, the adverse reaction score (DEC 0.5; ivermectin 1.5) and overall incidence (DEC 65.0%; ivermectin 93.3%) were significantly higher in the ivermectin group. Major adverse reactions were fever, headache and myalgia, all of which peaked on the second day post\u2010therapy. Efficacy was measured in terms of proportion of cases clearing parasitaemia and reduction in mean parasite density compared to pre\u2010therapy levels. Although at the end of one year the ivermectin group showed a significantly higher efficacy (34.8%, 97.0%) compared to DEC (8.3%, 83.8%), at the end of the second year there was no significant difference in efficacy between the drugs (73.7%, 99.5% for ivermectin; 47.8%, 98.9% for DEC). The tolerability and efficacy of the two drugs were not significantly different between gender, age and weight classes of patients.<\/jats:p>","DOI":"10.1046\/j.1365-3156.2000.00644.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T21:34:42Z","timestamp":1047504882000},"page":"779-785","source":"Crossref","is-referenced-by-count":20,"title":["Tolerability and efficacy of single\u2010dose diethyl carbamazine (DEC) or ivermectin in the clearance of <i>Wuchereria bancrofti<\/i> microfilaraemia in Pondicherry, south India"],"prefix":"10.1111","volume":"5","author":[{"given":"G.","family":"Subramanyam Reddy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Vengatesvarlou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. K.","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vanamail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P.","family":"Vijayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasi","family":"Kala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Pani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4269\/ajtmh.1993.48.178","article-title":"Comparative efficacy of clearing\u2010dose and single high\u2010dose ivermectin and diethylcarbamazine against Wuchereria bancrofti microfilaremia.","volume":"48","author":"Addiss DG","year":"1993","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_6_3_1","first-page":"307","article-title":"Comparative efficacy of annual and semi\u2010annual doses of ivermectin or diethylcarbamazine for the prevention of lymphatic filariasis.","volume":"40","author":"Cartel JL","year":"1992","journal-title":"Revue Epidemiologie et Sant\u00e9 Publique"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4269\/ajtmh.1994.50.339","article-title":"Ivermectin treatment of bancroftian filariasis in Recife, Brazil.","volume":"50","author":"Coutinho AD","year":"1994","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_6_5_1","article-title":"Towards elimination of lymphatic filariasis in India. Problems, challenges, opportunities and new initiatives.","author":"Das PK","year":"2000","journal-title":"Journal of the International Medical Science Academy"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90674-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(94)90241-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(98)90972-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(93)90045-D"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1001\/jama.1988.03720210040026","article-title":"Ivermectin for the treatment of Wuchereria bancrofti filariasis: efficacy and adverse reactions.","volume":"259","author":"Kumaraswami V","year":"1988","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000066646"},{"key":"e_1_2_6_12_1","first-page":"9","article-title":"Combination ivermectin plus diethylcarbamazine, a new effective tool for control of lymphatic filariasis.","volume":"46","author":"Moulia\u2010Pelat JP","year":"1995","journal-title":"Tropical Medicine and Parasitology"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/1996031045"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199004193221604"},{"key":"e_1_2_6_15_1","first-page":"491","article-title":"Strategies and tools for the control\/elimination of lymphatic filariasis.","volume":"75","author":"Ottesen EA","year":"1997","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1991.44.3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/00034983.1993.11812796","article-title":"A comparative study of the efficacy and tolerability of single and split doses of ivermectin and diethylcarbamazine in periodic brugian filariasis.","volume":"87","author":"Shenoy RK","year":"1993","journal-title":"Annals of Tropical Medicine and Parasitology"},{"key":"e_1_2_6_18_1","volume-title":"Lymphatic Filariasis: the Disease and its Control. Fifth report of the WHO expert committee on filariasis.WHO Technical Report Series 821","author":"WHO","year":"1992"},{"key":"e_1_2_6_19_1","first-page":"1","volume-title":"Lymphatic filariasis infection and diseases: Control strategies","author":"WHO","year":"1994"},{"key":"e_1_2_6_20_1","volume-title":"Lymphatic Filariasis: Reasons for Hope. WHO\/CTD\/ FIL\/97.4","author":"WHO","year":"1997"},{"key":"e_1_2_6_21_1","first-page":"83","article-title":"Effect of two single doses of ivermectin in treatment of asymptomatic bancroftian filariasis in two villages in the Nile Delta, Egypt.","volume":"27","author":"Youssef FG","year":"1997","journal-title":"Journal of the Egyptian Society of Parasitology"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-3156.2000.00644.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-3156.2000.00644.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T16:40:36Z","timestamp":1698597636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-3156.2000.00644.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["10.1046\/j.1365-3156.2000.00644.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-3156.2000.00644.x","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}