{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:23:57Z","timestamp":1780583037786,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2001,12,21]],"date-time":"2001-12-21T00:00:00Z","timestamp":1008892800000},"content-version":"vor","delay-in-days":111,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:p>We studied the effect of 10 annual distributions of ivermectin for control of human onchocerciasis on the reduction of <jats:italic>Onchocerca volvulus<\/jats:italic> transmission by <jats:italic>Simulium<\/jats:italic> vector flies. Prevalence and infection load in the human population decreased, whilst the annual biting rates (ABR) of the vector remained unchanged. The annual transmission potential of infective larvae of <jats:italic>O. volvulus<\/jats:italic> fell to 40% of the pre\u2010intervention level, but was still sufficient to maintain endemicity. However, recent immigration of herds of nomadic cattle into the study area has diverted the flies from man to cattle, creating an additional zooprophylactic effect. The predominant transmission of the bovine filaria <jats:italic>O. ochengi<\/jats:italic> to man also provides some concomitant cross\u2010protective immunity against further infestations with <jats:italic>O. volvulus<\/jats:italic>. The effects of ivermectin on <jats:italic>O. volvulus<\/jats:italic>, combined with the zooprophylactic effects of the increased cattle population, have produced a complex beneficial influence on the transmission of human onchocerciasis.<\/jats:p>","DOI":"10.1046\/j.1365-3156.2001.00771.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T21:37:38Z","timestamp":1047505058000},"page":"715-725","source":"Crossref","is-referenced-by-count":15,"title":["Combined benefits of annual mass treatment with ivermectin and cattle zooprophylaxis on the severity of human onchocerciasis in northern Cameroon"],"prefix":"10.1111","volume":"6","author":[{"given":"R.","family":"Seidenfaden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bonow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ekale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Tanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Renz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1051\/parasite\/1971465613","article-title":"Transmission of filariasis. 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