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The Ki\u201067 proliferative index (percentage of positive cells over 500 neoplastic cells) was low (&lt; 15%) in 55 cases and high (\u2a7e\u200315%) in 13 cases. High Ki\u201067 proliferative index and histological malignancy were both associated with significantly poorer 2\u2010year survival (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001). However, the predictive value of the Ki\u201067 proliferative index (97%) was higher than the predictive value of classical histology (91%). The evaluation of the growth fraction by the Ki\u201067 proliferative index is highly predictive of the biological behaviour of canine cutaneous melanoma.\n                  <\/jats:p>","DOI":"10.1046\/j.1365-3164.2001.00236.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T18:29:50Z","timestamp":1047493790000},"page":"139-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["MIB\u20101 immunoreactivity correlates with biologic behaviour in canine cutaneous melanoma"],"prefix":"10.1111","volume":"12","author":[{"given":"C.","family":"Laprie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Abadie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010F.","family":"Amardeilh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010L.L.E.","family":"Net","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lagadic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Delverdier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,21]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Bostock D.E.Neoplasia of the skin and mammary glands in dogs and cats.In: Kirk R.W. ed.Current Veterinary Therapy VI. 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