{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:01:28Z","timestamp":1771945288937,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,16]],"date-time":"2004-02-16T00:00:00Z","timestamp":1076889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The aim of our study was to investigate effects of 6\u2010week pretreatment of seasonal allergic rhinitis (AR) with cetirizine, and montelukast, alone and in combination. Antihistamine\/antileukotriene treatment is effective in AR. Antihistamines may prevent AR symptoms while prophylactic activity of antileukotrienes remains unclear.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Sixty AR patients, aged 18\u201335\u2003years, were randomized to receive placebo, montelukast only, cetirizine only, or montelukast plus cetirizine, 6\u2003weeks prior and 6\u2003weeks after the beginning of grass pollen season. Mean self\u2010recorded in\u2010season symptom scores and mean weekly all\u2010symptom scores were analyzed. In 31 patients, nasal lavages were performed before treatment, and at the end of the study, i.e. 12\u2003weeks after the treatment initiation. Eosinophil and basophil counts, eosinophil cationic protein (ECP), and mast cell tryptase (MCT) levels were evaluated in lavage samples.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Combined montelukast\/cetirizine pretreatment significantly reduced in\u2010season symptom score for sneezing, eye itching, nasal itching, rhinorrhea, and congestion. Montelukast plus cetirizine were more effective than cetirizine alone in preventing eye itching, rhinorrhea, and nasal itching. Moreover, combined pretreatment with montelukast and cetirizine delayed appearance of AR symptoms. Eosinophil nasal lavage fluid counts were significantly increased during pollen season in placebo and montelukast\u2010only groups. No differences were observed in basophil counts. The in\u2010season ECP level was significantly increased in all groups except montelukast\u2010plus\u2010cetirizine group. In\u2010season MCT levels were not increased.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Combined antihistamine and antileukotriene treatment started 6\u2003weeks before the pollen season is effective in preventing AR symptoms and reduces allergic inflammation in nasal mucosa during natural allergen exposure.<\/jats:p>","DOI":"10.1046\/j.1398-9995.2003.00416.x","type":"journal-article","created":{"date-parts":[[2004,12,18]],"date-time":"2004-12-18T19:31:01Z","timestamp":1103398261000},"page":"280-288","source":"Crossref","is-referenced-by-count":69,"title":["Montelukast plus cetirizine in the prophylactic treatment of seasonal allergic rhinitis: influence on clinical symptoms and nasal allergic inflammation"],"prefix":"10.1111","volume":"59","author":[{"given":"M.","family":"Kurowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"G\u00f3rski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,16]]},"reference":[{"key":"e_1_2_20_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90444-7"},{"key":"e_1_2_20_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90462-B"},{"key":"e_1_2_20_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90108-5"},{"key":"e_1_2_20_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80197-X"},{"key":"e_1_2_20_6_2","first-page":"597","article-title":"Mediator release after nasal airway challenge with 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